Malignant form of hidroacanthoma simplex: A case report

doi:10.12998/wjcc.v11.i24.5804

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World Journal of Clinical Cases

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Case Report

World J Clin Cases. Aug 26, 2023; 11(24): 5804-5810
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5804

Malignant form of hidroacanthoma simplex: A case report

Yi-Fei Yang, Rong Wang, Hui Xu, Wei-Guo Long, Xiao-Hui Zhao, Yu-Mei Li

Yi-Fei Yang, Rong Wang, Hui Xu, Yu-Mei Li, Department of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China

Wei-Guo Long, Xiao-Hui Zhao, Department of Pathology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China

Author contributions: Yang YF contributed to manuscript writing and editing, Wang R contributed to data collection; Long WG and Zhao XH contributed to data analysis; Xu H and Li YM contributed to conceptualization and supervision; all authors have read and approved the final manuscript.

Supported by Jiangsu Postgraduate Research Program, No. SJCX23_2102; Clinical and Virology Study of 2019-ncov Infection in Patients with Moderate to Severe Psoriasis, No. Jdfyxgzx005.

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to disclose.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Yu-Mei Li, Doctor, MD, PhD, Chief Doctor, Department of Dermatology, The Affiliated Hospital of Jiangsu University, No. 438 Jiefanglu Road, Zhenjiang 212001, Jiangsu Province, China. l.yumei@aliyun.com

Received: June 1, 2023
Peer-review started: June 1, 2023
First decision: July 19, 2023
Revised: July 29, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: August 26, 2023
Processing time: 84 Days and 19.5 Hours

Abstract

BACKGROUND

This paper presents a case of malignant hidroacanthoma simplex (HAS) and review the literature of previous cases to summarize the histopathological and immunohistochemical features and display the dermoscopic features of malignant HAS.

CASE SUMMARY

We present an 88-year-old Asian female with malignant HAS. The diagnosis was made according to the histopathological and immunohistochemical results after biopsy. Previous case reports of malignant HAS were retrieved from PubMed to characterize the histopathological and immunohistochemical features. We also display the dermoscopic features of malignant HAS that have not been reported.

CONCLUSION

Our findings demonstrate that prompt surgical treatment is an effective strategy for malignant HAS. Histopathology and immunohistochemistry are valuable diagnostic tools. This is the first case report to display the dermoscopic features of malignant HAS, and we speculate that dermoscopy may contribute to the diagnosis of malignant HAS.

Keywords: Malignant hidroacanthoma simplex; Dermoscopy; Immunohistochemistry; Histopathology; Diagnosis; Case report

Core Tip: Malignant hidroacanthoma simplex (HAS) is a clinically uncommon malignant cutaneous tumour with only a few case reports. Herein, we present an additional case of malignant HAS. By combining this case with a literature review of previous cases retrieved in PubMed, we summarize the histopathological and immunohistochemical features of malignant HAS and found that timely surgical operation is an effective treatment. Furthermore, we first display dermoscopic features of malignant HAS and speculate that dermoscopy may be a valuable tool for the early diagnosis of malignant HAS.