Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5710-5720
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5710
Efficacy and safety of Huangqi Jianzhong decoction in the treatment of chronic atrophic gastritis: A meta-analysis
Xin-Peng Yan, Wen Si, Ming-Sheng Ding, Yuan-Fen Tian, Zhuang Guo
Xin-Peng Yan, Ming-Sheng Ding, Department of Traditional Chinese Medicine, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Wen Si, Department of Endocrinology, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Yuan-Fen Tian, Children’s Rehabilitation and Health Care Department, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Zhuang Guo, Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying 257034, Shandong Province, China
Author contributions: Yan XP, Guo Z contributed to conceptualization, methodology, project administration, resources, contributed to software, visualization, writing-review & editing; Si W contributed to data curation; Ding MS contributed to formal analysis; Tian YF contributed to investigation; Guo Z contributed to supervision and validation; Yan XP contributed to writing -original draft.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhuang Guo, MD, Attending Doctor, Department of Gastroenterology, Shengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying 257034, Shandong Province, China. guozhuangvx25@163.com
Received: July 10, 2023
Peer-review started: July 10, 2023
First decision: July 18, 2023
Revised: July 22, 2023
Accepted: July 31, 2023
Article in press: July 31, 2023
Published online: August 26, 2023
Processing time: 46 Days and 0.4 Hours
Abstract
BACKGROUND

Chronic atrophic gastritis is a persistent disorder of the digestive system where the gastric mucosa epithelium and glands undergo atrophy, leading to a decrease in their number and thinning of the gastric mucosa. It is worth noting that the prevalence of chronic atrophic gastritis is higher in China compared to the global average, and it is also considered a precancerous condition for gastric cancer.

AIM

To evaluate the efficacy of Huangqi Jianzhong decoction in treating chronic atrophic gastritis. Chronic atrophic gastritis is a persistent illness characterized by the progressive disappearance of healthy gastric glands due to repeated injury. Huangqi Jianzhong decoctions are widely used in China to treat chronic atrophic gastritis. However, there is limited scientific evidence regarding their efficacy in treating this illness.

METHODS

The present meta-analysis adhered to the PRISMA guidelines and used the Cochrane Collaboration methodology. We performed a comprehensive search for clinical trials investigating the use of Huangqi Jianzhong decoction in treating chronic atrophic gastritis published until January 2023. The risk of bias and the quality of the included studies were evaluated using the Cochrane Handbook guidelines. Finally, a meta-analysis was conducted using the RevMan 5.4 software.

RESULTS

This study included a total of 13 articles, comprising 1269 samples. The meta-analysis was conducted on these 13 articles, yielding the following results: I2 = 0%, P = 0.60, [RR = 1.24, 95%CI: 1.18 to 1.30, P < 0.00001]. The forest plot analysis of the Helicobacter pylori clearance rate revealed I2 = 0%, P = 0.36, [RR = 1.20, 95%CI: 1.05 to 1.38, P = 0.009]. The forest plot of PG-I level showed I2 = 99%, P < 0.00001, [MD = 4.99, 95%CI: -1.59 to 11.58, P = 0.14]. The forest plot of stomach pain demonstrated I2 = 54%, P = 0.04, [MD = -0.63, 95%CI: -0.68 to -0.58, P < 0.00001]. The forest plot of reflux indicated I2 = 82%, P = 0.0009, [MD = -0.48, 95%CI: -0.63 to -0.33, P < 0.00001]. The forest plot of recurrence rate exhibited I2 = 0%, P = 0.92, [RR = 0.15, 95%CI: 0.04 to 0.66, P = 0.01]. The forest plot of adverse reactions showed no heterogeneity in outcome data, [RR = 1.07, 95%CI: 0.53 to 2.17, P = 0.86].

CONCLUSION

This study demonstrated that Huangqi Jianzhong decoction improved various factors in adults with chronic atrophic gastritis. These factors included the total effective rate, Helicobacter pylori clearance rate, symptoms such as stomachache and acid reflux alleviation, and recurrence rates.

Keywords: Meta-analysis; Chronic atrophic gastritis; Huangqi Jianzhong decoction; Safety

Core Tip: Chronic atrophic gastritis is a chronic disease featured by the gradual disappearance of normal glands after being damaged repeatedly. We conducted a meta-analysis using Revman 5.4, and the study showed that Huangqi Jianzhong Tang (HQT) can effectively improve the symptoms of chronic atrophic gastritis and enhance patients’ quality of life. We advocate the integration of traditional Chinese medicine in clinical practice for treating diseases, and our research provides theoretical support for the clinical use of HQT in the treatment of chronic atrophic gastritis.