Zhou YT, Wang RY, Zhang Y, Li DY, Yu J. Local hyperthermia combined with chemotherapy for the treatment of multiple recurrences of undifferentiated pleomorphic sarcoma: A case report. World J Clin Cases 2022; 10(9): 2916-2922 [PMID: 35434094 DOI: 10.12998/wjcc.v10.i9.2916]
Corresponding Author of This Article
Jian Yu, MMed, Chief Doctor, Professor, Hyperthermia Center, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian 110006, China. dlyujian1127@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 26, 2022; 10(9): 2916-2922 Published online Mar 26, 2022. doi: 10.12998/wjcc.v10.i9.2916
Local hyperthermia combined with chemotherapy for the treatment of multiple recurrences of undifferentiated pleomorphic sarcoma: A case report
Yi-Ting Zhou, Ruo-Yu Wang, Yao Zhang, Dong-Yi Li, Jian Yu
Yi-Ting Zhou, Jian Yu, Hyperthermia Center, The Affiliated Zhongshan Hospital of Dalian University, Dalian 110006, China
Ruo-Yu Wang, Department of Medical Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian 110006, China
Yao Zhang, Dong-Yi Li, Department of Bone and Soft Tissue Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian 110006, China
Author contributions: Zhou YT and Yu J were the patient’s medical oncologists, reviewed the literature and drafted the manuscript; Zhang Y and Li DY were the patient’s surgeons, performed the surgery and analyzed the results; Wang RY analyzed and interpreted the imaging findings, reviewed the literature and drafted the manuscript; Wang RY and Yu J were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Yu, MMed, Chief Doctor, Professor, Hyperthermia Center, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian 110006, China. dlyujian1127@163.com
Received: October 6, 2021 Peer-review started: October 6, 2021 First decision: December 10, 2021 Revised: December 19, 2021 Accepted: February 15, 2022 Article in press: February 15, 2022 Published online: March 26, 2022 Processing time: 167 Days and 4.6 Hours
Abstract
BACKGROUND
Undifferentiated pleomorphic sarcoma (UPS) is a type of soft tissue sarcoma, the histologic origin and differentiation direction of which are still unclear. There are few treatment options for UPS other than surgery. Herein we describe a patient who had multiple recurrences of UPS postoperatively, but R0 resection was achieved by local hyperthermia combined with chemotherapy, thus providing a new treatment approach for similar situations.
CASE SUMMARY
A 65-year-old man sought evaluation from a physician for a mass on his right back. After surgery, the pathologic diagnosis was fibrosarcoma. During the follow-up evaluations until 2021, the patient had four relapses of varying degrees. Postoperative pathology confirmed the recurrence of UPS on the right back. In March 2021, he underwent local hyperthermia combined with two cycles of chemotherapy for recurring lesions. After magnetic resonance imaging re-examination and preoperative examination, the patient chose surgery again. During the operation, the tumors were easy to excise, the amount of bleeding decreased significantly, and the pathologic evaluation confirmed that one of the specimens was an R0 excision.
CONCLUSION
Local hyperthermia combined with chemotherapy enables R0 resection to be achieved in patients with advanced UPS recurrence.
Core Tip: Undifferentiated pleomorphic sarcoma is a type of soft tissue sarcoma, but the histologic origin and direction of differentiation are still unclear. Patients with locally advanced, unresectable, or metastatic disease have a poor prognosis, and there are few treatment options available. Clinically, local hyperthermia combined with chemotherapy can be used to achieve surgical R0 resection in this type of patient.
