Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2216
Peer-review started: March 24, 2021
First decision: October 16, 2021
Revised: October 27, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: March 6, 2022
Processing time: 342 Days and 21.6 Hours
Quetiapine, known as a non-classical antipsychotic drug, is frequently used for the treatment of mental diseases, such as schizophrenia, bipolar disorder, and major depressive disorder. Acute lung injury, a rarely reported side effect of quetiapine, is described in this case report.
Due to terminal delirium, a 66-year-old man took a large dose of quetiapine and then developed severe pulmonary disease. His symptoms were not resolved after routine treatment, such as antibiotics, diuretic, and supportive therapies. Quetiapine-related acute lung injury was therefore suspected and hormonal therapy was initiated. Subsequently, his symptoms were alleviated and the radiological results improved dramatically.
Our findings in the present report highlight a potential adverse effect of quetiapine, drug-related acute lung injury, which deserves awareness in clinical practice.
Core Tip: Quetiapine is a non-classic antipsychotic drug. Acute lung injury, a rarely reported side effect of quetiapine, is described in this case report. Common etiologies were ruled out when the patient’s symptoms were not resolved after routine treatment. Finally, quetiapine-related acute lung injury was suspected and hormonal therapy was initiated. The patient’s symptoms were alleviated and the radiological results improved. The case report highlights this potential adverse effect of quetiapine, which deserves more awareness in clinical practice.