Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells: A case report

doi:10.12998/wjcc.v10.i34.12665

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World Journal of Clinical Cases

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Case Report

World J Clin Cases. Dec 6, 2022; 10(34): 12665-12670
Published online Dec 6, 2022. doi: 10.12998/wjcc.v10.i34.12665

Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells: A case report

Jun-Seob Song, Ki-Taek Hong, Ki Jeon Song, Seok Jung Kim

Jun-Seob Song, Ki-Taek Hong, Department of Orthopedic Surgery, Gangnam JS Hospital, Seoul 06053, South Korea

Ki Jeon Song, Seok Jung Kim, Department of Orthopedic Surgery, Uijeongbu Street Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 11765, Gyeonggi-do, South Korea

Author contributions: Song JS and Song KJ conceived the study and wrote the manuscript; Hong KT participated in its design and coordination and helped to draft the manuscript; Kim SJ analyzed data; All authors read and approved the final manuscript.

Informed consent statement: Informed written consent was obtained from the patient’s parents.

Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Seok Jung Kim, FRCS, MD, PhD, Director, Full Professor, Department of Orthopedic Surgery, Uijeongbu Street Mary’s Hospital, College of Medicine, The Catholic University of Korea, No. 271 Cheonbo-ro, Uijeongbu 11765, Gyeonggi-do, South Korea. peter@catholic.ac.kr

Received: July 10, 2022
Peer-review started: July 10, 2022
First decision: August 22, 2022
Revised: September 10, 2022
Accepted: November 2, 2022
Article in press: November 2, 2022
Published online: December 6, 2022
Processing time: 145 Days and 1.1 Hours

Abstract

BACKGROUND

Patellar dislocation may cause cartilage defects of various sizes. Large defects commonly require surgical treatment; however, conventional treatments are problematic.

CASE SUMMARY

A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation. To our knowledge, this is the first report of this treatment for this purpose. The patient recovered well as indicated by good visual analog scale, International Knee Documentation Committee and McMaster Universities Osteoarthritis Index scores. Magnetic resonance imaging showed cartilage regeneration 18 mo postoperatively.

CONCLUSION

Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

Keywords: Cartilage defect; Umbilical cord; Mesenchymal stem cells; Patellar dislocation; Magnetic resonance imaging; Case report

Core Tip: Umbilical cord blood-derived mesenchymal stem cells consist of a unique population of progenitors co-expressing mesenchymal stem cells and neuronal markers capable of instantaneous differentiation. This report is of a 15-year-old male teen with a large patellar cartilage defect due to patellar dislocation who was treated with implantation of human umbilical cord blood-derived mesenchymal stem cells.