Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2022; 10(12): 3866-3871
Published online Apr 26, 2022. doi: 10.12998/wjcc.v10.i12.3866
Ischemic colitis after receiving the second dose of a COVID-19 inactivated vaccine: A case report
Mei-Hua Cui, Xiao-Lin Hou, Jun-Yuan Liu
Mei-Hua Cui, Xiao-Lin Hou, Jun-Yuan Liu, Department of Gastroenterology, Aerospace Center Hospital, Beijing 100049, China
Author contributions: Cui MH conceived and designed the case report, analyzed the data and wrote the manuscript; Hou XL participated in discussion and analysis of the case; Liu JY performed the literature review; All the authors read and approved the final version of this manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei-Hua Cui, PhD, Doctor, Department of Gastroenterology, Aerospace Center Hospital, No. 15 Yuquan Road, Haidian District, Beijing 100049, China. cuimeih@sina.com
Received: August 16, 2021
Peer-review started: August 16, 2021
First decision: October 22, 2021
Revised: November 4, 2021
Accepted: March 6, 2022
Article in press: March 6, 2022
Published online: April 26, 2022
Processing time: 247 Days and 21.9 Hours
Abstract
BACKGROUND

The outbreak of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has been the most important clinical challenge worldwide since January 2020. COVID-19 inactivated vaccines play a crucial role in reducing the rates of morbidity and mortality.

CASE SUMMARY

We presented a 48-year-old woman from Haidian District, Beijing, China who developed ischemic colitis after receiving the second dose of COVID-19 inactivated vaccine. Computed tomography of the abdomen showed edema and bowel wall thickening with hypodensity in the sigmoid colon and descending colon. Colonoscopy revealed hyperemia, edema and erosion of the mucosa with superficial ulceration and a yellow-white coating at the descending colon and sigmoid colon. The symptoms were relieved after 1 wk of receiving pinaverium bromide (50 mg, tid) and aspirin enteric-coated tablets (0.1 g, qd).

CONCLUSION

The possible occurrence of ischemic colitis should be considered after administration of the COVID-19 inactivated vaccines.

Keywords: COVID-19; Vaccine; Ischemic colitis; Adverse event; Case report

Core Tip: Coronavirus disease 2019 (COVID-19) inactivated vaccines play a crucial role in reducing the rates of morbidity and mortality. The adverse events after administration of inactivated vaccines are varied and need to be profoundly studied in clinical practice. This report described the relationship between the administration of the COVID-19 inactivated vaccine with ischemic colitis and its possible causes. The potential mechanism behind the development of ischemic colitis needs further exploration to better understand and manage unforeseen complications of COVID-19 inactivated vaccines.