Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3496
Peer-review started: August 9, 2021
First decision: November 17, 2021
Revised: December 5, 2021
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Processing time: 241 Days and 19.8 Hours
Ductal carcinoma in situ (DCIS) arising within fibroadenoma is a type of tumor that is rarely encountered in clinic, with only about 100 cases of carcinoma arising within a fibroadenoma reported in the literature. Here, we present two cases of breast DCIS arising within a fibroadenoma and discuss their clinical and imaging findings as well as treatment.
The patients did not have cancer-related personal and family histories. Case 1 (a 49-year-old woman) was diagnosed with a bilateral breast nodule in May 2018 and was followed (preoperative imaging data including ultrasound and mammography) for 3 years; she underwent an excisional biopsy to address an enlargement in nodule size. Case 2 (a 37-year-old woman) was diagnosed with a left breast nodule in June 2021 and consequently received vacuum-assisted biopsy of the tumor which appeared as “irregularly shaped” and “unevenly textured” tissue on ultrasound. The pathological diagnosis was clear in both cases. Both patients underwent breast-conserving surgery and sentinel lymph node biopsy. The two cases received or planned to receive radiotherapy as well as endocrine therapy (tamoxifen).
Breast DCIS arising within a fibroadenoma is rare, but patients treated with radiotherapy and endocrine therapy can have good prognosis.
Core Tip: Breast ductal carcinoma in situ arising within a fibroadenoma is a rare event. We present 2 such cases and discuss their clinical and imaging findings as well as treatment. Both patients underwent breast-conserving surgery and sentinel lymph node biopsy. The 2 cases received or planned to receive radiotherapy as well as endocrine therapy (tamoxifen). More sections are needed to reduce the missed rate. Complete follow-up data with preoperative imaging can help with decision-making during patient follow-up.