Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals

Figure 1 Elevated baseline hyaluronic acid and type III procollagen N-peptide was associated with treatment failure. A: Distribution of hyaluronic acid serum levels between non-responders and responders according to sustained virological response after treatment; B: Distribution of type III procollagen N-peptide serum levels between non-responders and responders according to sustained virological response after treatment; C; As revealed by receiver operating characteristic curve analysis hyaluronic acid have a good ability in predicting treatment response; D: As revealed by receiver operating characteristic curve analysis type III procollagen N-peptide have a good ability in predicting treatment response. HA: Hyaluronic acid; PIIINP: Type III procollagen N-peptide; SVR: Sustained virological response; AUC: Area under the receiver operating characteristic curve.

Figure 2 Index development and treatment failure prediction. A: Multiplication of hyaluronic acid (HA) by type III procollagen N-peptide (PIIINP) values is the beast model for significant prediction of treatment failure; B: The best cut-off points of HA × PIIINP model is 1840 μg/mL; C: At this value, HA × PIIINP model has good and significant ability for early distinguishing non-responders from patients with sustained virological response 24. HA: Hyaluronic acid; PIIINP: Type III procollagen N-peptide; SVR: Sustained virological response; AUC: Area under the receiver operating characteristic curve.