Prospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Jun 25, 2025; 14(2): 106479
Published online Jun 25, 2025. doi: 10.5501/wjv.v14.i2.106479
Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals
Mohamed A Abdelrazek, Ahmed I Elghwab, Ashraf A Tabll, Elsherbiny H Elsayed, Mohammed El Behery
Mohamed A Abdelrazek, Department of Research and Development, Biotechnology Research Center, New Damietta 34517, Egypt
Mohamed A Abdelrazek, Sherbin Central Hospital, Ministry of Health and Population, Shirbin City 35661, Egypt
Ahmed I Elghwab, Elsherbiny H Elsayed, Mohammed El Behery, Department of Chemistry, Faculty of Science, Port Said University, Port Said 8525502, Egypt
Ashraf A Tabll, Department of Microbial Biotechnology, National Research Centre, Dokki 12622, Egypt
Ashraf A Tabll, Department of Immunology, Egypt Centre for Research and Regenerative Medicine, Cairo 11517, Egypt
Author contributions: Abdelrazek MA and Tabll AA conceptualized the study; Abdelrazek MA and Elghwab AI were involved in investigation and the methodology development; Elsayed EH and El Behery M were involved in validation of the study; Abdelrazek MA, Tabll AA, Elsayed EH, and El Behery M supervised the study; and all authors read and approved the final manuscript version to be published.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Faculty of Medicine, Port Said University, approval No. MED (1/6/2023) s.no (96) BIO 004.
Clinical trial registration statement: Not applicable.
Informed consent statement: Prior to participating, all participants provided informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: Patient information was handled with strict confidentiality and privacy throughout the entire process.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohamed A Abdelrazek, PhD, Associate Research Scientist, Consultant, Researcher, Department of Research and Development, Biotechnology Research Center, 23 July Street, Industrial Zone, New Damietta 34517, Egypt. maabdelrazek@yahoo.com
Received: February 27, 2025
Revised: April 4, 2025
Accepted: May 7, 2025
Published online: June 25, 2025
Processing time: 116 Days and 12.6 Hours
Core Tip

Core Tip: In any medical therapy, treatment response proper prognosis is very important to reduce impacts of the medication and the disease as well. This study highlighted the significant role of hyaluronic acid and type III procollagen N-peptide in the prediction of hepatitis C virus direct-acting antivirals treatment response. Findings revealed that multiplying hyaluronic acid with type III procollagen N-peptide values increase the sensitivity to detect treatment success (74.7% sensitivity, 74% specificity and 74.3% accuracy).