Cytomegalovirus reactivation and the prevalence in autologous hematopoietic stem cell transplantation

doi:10.5501/wjv.v15.i1.117651

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Mar 25, 2026 (publication date) through Mar 13, 2026

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World Journal of Virology

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2220-3249

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Virol. Mar 25, 2026; 15(1): 117651
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.117651

Cytomegalovirus reactivation and the prevalence in autologous hematopoietic stem cell transplantation

Agastya Mittal, Hunter J Hutchinson, Brandon P Lucke-Wold

Agastya Mittal, Hunter J Hutchinson, College of Medicine, University of Florida, Gainesville, FL 32601, United States

Brandon P Lucke-Wold, Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL 32608, United States

Author contributions: Mittal A was responsible for data collection and writing the original draft; Hutchinson HJ was responsible for writing review and editing; Lucke-Wold BP was responsible for supervision and writing review; all authors read and approved the final manuscript to be published.

Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.

Corresponding author: Brandon P Lucke-Wold, MD, PhD, Academic Fellow, Lillian S. Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Road, Gainesville, FL 32608, United States. brandon.lucke-wold@neurosurgery.ufl.edu

Received: December 12, 2025
Revised: January 9, 2026
Accepted: January 27, 2026
Published online: March 25, 2026
Processing time: 91 Days and 15.1 Hours

Core Tip

Core Tip: Reactivation of cytomegalovirus (CMV) is a crucial consideration in autologous hematopoietic stem cell transplantation (AHSCT), yet it is often overlooked. Given the increasing prevalence of CMV reactivation in AHSCT, centralized guidelines for its screening and assessment would improve patient outcomes. This is especially pertinent given the high mortality rate of CMV reactivation in AHSCT.