Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Virol. Mar 25, 2026; 15(1): 115210
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.115210
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.115210
Rift Valley fever: An emerging zoonotic threat to global health and agriculture
Praveen Kumar Uppala, Department of Pharmacology, Maharajah's College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Sita Kumari Karanam, Department of Pharmaceutical Biotechnology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Naga Vishnu Kandra, Department of Pharmacology, Santhiram Medical College and General Hospital, Nandyal 518501, Andhra Pradesh, India
Sandhya Edhi, Department of Pharmacognosy, Andhra University College of Pharmaceutical Sciences, Visakhapatnam 530003, Andhra Pradesh, India
Author contributions: Uppala PK was responsible for preparation and supervision of manuscript; Karanam SK was responsible for final revision of manuscript; Kandra NV was responsible for collection of material; Edhi S was responsible for literature search; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Praveen Kumar Uppala, Assistant Professor, Researcher, Department of Pharmacology, Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Received: October 14, 2025
Revised: November 22, 2025
Accepted: December 29, 2025
Published online: March 25, 2026
Processing time: 153 Days and 21 Hours
Revised: November 22, 2025
Accepted: December 29, 2025
Published online: March 25, 2026
Processing time: 153 Days and 21 Hours
Core Tip
Core Tip: Rift Valley fever is a re-emerging zoonotic disease with significant health and economic impacts across Africa and the Middle East. This mini-review comprehensively discusses its virology, transmission, clinical manifestations, and challenges in diagnosis, treatment, and vaccine development. It highlights current outbreak trends, environmental and socioeconomic factors, and emphasizes the urgent need for global surveillance, intersectoral collaboration, and the development of effective prevention and control strategies for Rift Valley fever.