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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Sep 25, 2025; 14(3): 107905
Published online Sep 25, 2025. doi: 10.5501/wjv.v14.i3.107905
Published online Sep 25, 2025. doi: 10.5501/wjv.v14.i3.107905
Non hepatotropic virus induced hepatitis - rising importance in a changing world
Gautam Ray, Gastroenterology Unit, Department of Medicine, B.R. Singh Railway Hospital, Kolkata 700014, West Bengal, India
Author contributions: Ray G designed the manuscript, collected all references, did the write up and critical appraisal of the script.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gautam Ray, MD, Additional Chief Health Director, Gastroenterology Unit, Department of Medicine, B.R. Singh Railway Hospital, Sealdah, Kolkata 700014, West Bengal, India. gautam1910@yahoo.com
Received: April 2, 2025
Revised: May 9, 2025
Accepted: August 4, 2025
Published online: September 25, 2025
Processing time: 178 Days and 18.1 Hours
Revised: May 9, 2025
Accepted: August 4, 2025
Published online: September 25, 2025
Processing time: 178 Days and 18.1 Hours
Core Tip
Core Tip: Liver infection by non-hepatotropic viruses is increasingly being encountered in the setting of emerging and re-emerging viral diseases the world over and the increasing use of immune altering medications in situations like organ transplant, immune mediated diseases and cancers, especially in the aging world population living with many comorbidities. Symptomatology can range from self-limited transaminitis in the immunocompetent to disseminated disease with acute liver failure in the immunocompromised. They are seldom detected as most infections have non-specific presentation and are self-limited. Early diagnosis can prevent complications. This review summarizes their epidemiology, clinical manifestations and management.