Alam R. Atypical presentation of pediatric acute hepatitis A: Is the situation alarming? World J Virol 2025; 14(4): 114174 [DOI: 10.5501/wjv.v14.i4.114174]
Corresponding Author of This Article
Rubaiyat Alam, Assistant Professor, Department of Pediatric Gastroenterology and Nutrition, Bangladesh Medical University, Shahbag, Dhaka 1000, Bangladesh. dr.rubaiyat@yahoo.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 25, 2025 (publication date) through Dec 25, 2025
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Journal Information of This Article
Publication Name
World Journal of Virology
ISSN
2220-3249
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Alam R. Atypical presentation of pediatric acute hepatitis A: Is the situation alarming? World J Virol 2025; 14(4): 114174 [DOI: 10.5501/wjv.v14.i4.114174]
World J Virol. Dec 25, 2025; 14(4): 114174 Published online Dec 25, 2025. doi: 10.5501/wjv.v14.i4.114174
Atypical presentation of pediatric acute hepatitis A: Is the situation alarming?
Rubaiyat Alam
Rubaiyat Alam, Department of Pediatric Gastroenterology and Nutrition, Bangladesh Medical University, Dhaka 1000, Bangladesh
Author contributions: Alam R solely contributed to the conception, literature review, drafting, and revision of the manuscript, approved the final version, and is responsible for the integrity of the entire work.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rubaiyat Alam, Assistant Professor, Department of Pediatric Gastroenterology and Nutrition, Bangladesh Medical University, Shahbag, Dhaka 1000, Bangladesh. dr.rubaiyat@yahoo.com
Received: September 15, 2025 Revised: November 6, 2025 Accepted: December 3, 2025 Published online: December 25, 2025 Processing time: 103 Days and 20.6 Hours
Abstract
Hepatitis A virus (HAV) infection remains a significant public health concern in many developing countries. The annual incidence of HAV infection is 1.5 million, though this figure may be underestimated owing to the infection’s asymptomatic nature and the presence of milder disease variants. The clinical spectrum of HAV infection now ranges from asymptomatic infection to fulminant hepatitis. Despite the availability of safe and highly effective vaccines, HAV infections remain a major contributor to acute viral hepatitis worldwide.
Core Tip: Although pediatric hepatitis A is usually self-limiting, atypical presentations, such as cholestatic, relapsing, and autoimmune-triggered forms, can prolong morbidity and, occasionally, be life-threatening. This mini-review summarizes the clinical spectrum, highlights warning signs of severe disease, and outlines practical management and prevention strategies, with a particular emphasis on vaccination.
