Tüsüz Önata E, Özdemir Ö. Microbiome, dysbiosis and use of probiotics in various diseases. World J Virol 2025; 14(2): 99574 [DOI: 10.5501/wjv.v14.i2.99574]
Corresponding Author of This Article
Öner Özdemir, MD, Professor, Division of Allergy and Immunology, Department of Pediatrics, Sakarya Research and Training Hospital, Sakarya University, Faculty of Medicine, Adnan Menderes Cad, Sağlık Sok, No. 195 Adapazarı, Sakarya 54100, Türkiye. onerozdemir@sakarya.edu.tr
Research Domain of This Article
Allergy
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Virol. Jun 25, 2025; 14(2): 99574 Published online Jun 25, 2025. doi: 10.5501/wjv.v14.i2.99574
Microbiome, dysbiosis and use of probiotics in various diseases
Ece Tüsüz Önata, Öner Özdemir
Ece Tüsüz Önata, Öner Özdemir, Division of Allergy and Immunology, Department of Pediatrics, Sakarya Research and Training Hospital, Sakarya University, Faculty of Medicine, Sakarya 54100, Türkiye
Author contributions: Tüsüz Önata E and Özdemir Ö have done everything; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Öner Özdemir, MD, Professor, Division of Allergy and Immunology, Department of Pediatrics, Sakarya Research and Training Hospital, Sakarya University, Faculty of Medicine, Adnan Menderes Cad, Sağlık Sok, No. 195 Adapazarı, Sakarya 54100, Türkiye. onerozdemir@sakarya.edu.tr
Received: July 25, 2024 Revised: December 18, 2024 Accepted: January 2, 2025 Published online: June 25, 2025 Processing time: 332 Days and 23.5 Hours
Abstract
The community of microorganisms that colonize certain areas of the human body is called microbiota. Microorganisms such as bacteria, fungi and viruses make up the microbiota. The sum of the genomes of these microorganisms and microorganisms refers to the microbiome. It has been shown that microbiota has important effects such as protecting the organ from pathogens, contributing to metabolic functions (such as vitamin synthesis, carbohydrate digestion) and providing immunoregulation. Dysbiosis refers to compositional and functional changes in the microbiota. At the beginning of the 21st century, numerous studies have investigated the human microbiota and its imbalance in relation to various diseases and found that dysbiosis is associated with many diseases. The aim of this mini-review article is to provide brief information about dysbiosis and its care and to raise awareness.
Core Tip: Dysbiosis refers to compositional and functional changes in the microbiota that cause disruption of the resistance and resilience of the microbial ecosystem. Correction of dysbiosis by beneficial bacteria such as probiotics can be a useful treatment for allergic diseases.
