Expression differences and relationships of endothelin-1, interleukin-6 and c-kit in hypertensive patients with and without depression

Table 1 Comparison of clinical data between group a and group B, n (%)

Clinical data	Group A (n = 77)	Group B (n = 86)	t/χ2	P value
Gender (male)	42 (54.55)	45 (52.33)	0.080	0.776
Age (years)	53.74 ± 11.79	54.32 ± 10.85	0.327	0.744
BMI (kg/m²)	23.18 ± 3.73	22.76 ± 3.95	0.695	0.487
Smoking status	28 (36.36)	34 (39.53)	0.173	0.677
Alcohol consumption	12 (15.58)	11 (12.79)	0.261	0.609
Duration of hypertension (years)	4.92 ± 1.43	5.17 ± 1.79	0.977	0.329
SBP (mmHg)	152.39 ± 7.87	153.48 ± 8.12	0.868	0.386
DBP (mmHg)	94.19 ± 9.93	94.35 ± 10.21	0.101	0.919
TC (mmol/L)	4.73 ± 1.15	4.62 ± 1.28	0.574	0.566
TG (mmol/L)	1.33 ± 0.72	1.39 ± 0.82	0.493	0.622
LDL-C (mmol/L)	2.78 ± 0.74	2.85 ± 0.72	0.611	0.541
HDL-C (mmol/L)	1.41 ± 0.73	1.32 ± 0.77	0.763	0.446
FBG (mmol/L)	4.97 ± 0.38	5.09 ± 0.52	1.665	0.097
BUN (mmol/L)	5.12 ± 1.33	4.94 ± 1.45	0.822	0.411
Cr (μmol/L)	69.74 ± 11.45	70.37 ± 12.16	0.339	0.734
UA (μmol/L)	311.78 ± 76.95	316.43 ± 80.52	0.375	0.707
Use of amlodipine	6 (7.79)	5 (5.81)	0.252	0.615

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; TC: Total cholesterol; TG: Triglycerides; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; FBG: Fasting blood glucose; BUN: Blood urea nitrogen; Cr: Creatinine; UA: Uric acid.

Table 2 Variable assignment

Independent variable	Assignment method
ET-1	Original value
IL-6	Original value
SCF	Original value
c-kit	Original value

ET-1: Endothelin-1; IL-6: Interleukin-6; SCF: Stem cell factor.

Table 3 Multivariate logistic regression analysis of factors influencing hypertension with depression

Factor	β	SE	Wald χ2	P value	OR	95%CI
ET-1	1.086	0.372	8.674	< 0.001	2.893	1.281-6.519
IL-6	1.148	0.411	7.657	< 0.001	1.775	1.216-4.158
SCF	-1.153	0.364	9.481	< 0.001	0.715	0.463-0.972
c-kit	-1.224	0.537	10.752	< 0.001	0.643	0.368-0.835

ET-1: Endothelin-1; IL-6: Interleukin-6; SCF: Stem cell factor.

Table 4 Diagnostic value of endothelin-1, interleukin-6, stem cell factor c-kit, and their combination for hypertension with depression

Indicator	Optimal cutoff value	AUC	95%CI	P value	Sensitivity (%)	Specificity (%)
ET-1	165.73 ng/L	0.746	0.675-0.832	< 0.05	72.56	75.38
IL-6	96.04 ng/L	0.801	0.743-0.889	< 0.05	75.43	67.62
SCF	847.36 ng/L	0.732	0.654-0.817	< 0.05	70.85	74.19
c-kit	11.53 μg/L	0.779	0.707-0.876	< 0.05	77.62	70.57
Combined	-	0.884	0.813-0.957	< 0.05	90.24	85.37

ET-1: Endothelin-1; IL-6: Interleukin-6; SCF: Stem cell factor; AUC: Area under the curve.