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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2025; 15(7): 106733
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.106733
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.106733
Expression differences and relationships of endothelin-1, interleukin-6 and c-kit in hypertensive patients with and without depression
Wei-Yi Wang, Yi Wu, Jing-Qi Zhang, Bin Li, The Clinical Research Center for Acute Myocardial Infarction of Hubei Province, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437000, Hubei Province, China
Wei-Yi Wang, Jing-Qi Zhang, Laboratory of Cardiovascular Internal Medicine Department, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Wang WY, Wu Y designed the research study; Zhang JQ performed the research; Li B conducted experiments, analyzed the data. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The First Affiliated Hospital of Harbin Medical University and strictly adhered to the ethical guidelines of the Declaration of Helsinki.
Informed consent statement: Informed consent was obtained from all study participants.
Conflict-of-interest statement: The authors declare that they have no competing interests
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Li, Chief Physician, The Clinical Research Center for Acute Myocardial Infarction of Hubei Province, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, No. 228 Jingui Road, Xianning 437000, Hubei Province, China. 17807238940@163.com
Received: March 28, 2025
Revised: April 17, 2025
Accepted: May 21, 2025
Published online: July 19, 2025
Processing time: 103 Days and 19.9 Hours
Revised: April 17, 2025
Accepted: May 21, 2025
Published online: July 19, 2025
Processing time: 103 Days and 19.9 Hours
Core Tip
Core Tip: Compared to patients with hypertension alone, patients with hypertension and depression exhibited higher serum levels of endothelin-1 (ET-1) and interleukin-6 (IL-6) and lower levels of stem cell factor (SCF) and c-kit. High ET-1, high IL-6, low SCF, and low c-kit were independent influencing factors for hypertension with depression. The combination of ET-1, IL-6, SCF, and c-kit demonstrated significant diagnostic value for hypertension with depression.