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World J Psychiatry. May 19, 2026; 16(5): 115867
Published online May 19, 2026. doi: 10.5498/wjp.v16.i5.115867
Published online May 19, 2026. doi: 10.5498/wjp.v16.i5.115867
Meta-analysis of dopaminergic-serotonergic modulation strategies for depressive symptoms in Parkinson’s disease
Cheng-Cheng Li, Yan Zhou, Li Zhang, Wen-Lie Gu, Hong Gu, Department of Pharmacy, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou 214500, Jiangsu Province, China
Cheng-Cheng Li, Kai-Xia Chen, Clinical Trial Agency Office, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou 214500, Jiangsu Province, China
Co-first authors: Cheng-Cheng Li and Yan Zhou.
Co-corresponding authors: Kai-Xia Chen and Hong Gu.
Author contributions: Li CC and Zhou Y are co-first authors of this manuscript, they contributed equally and jointly participate in research design, data collection, and organization. They collaborate to complete statistical analysis and write and revise the initial draft of the paper. They are responsible for the core content of the research and the authenticity of the data. Chen KX and Gu H are co-corresponding authors of this manuscript. Chen KX and Gu H jointly coordinate the overall research process, review the research plan and data analysis results, and deeply revise the final draft of the paper; Chen KX is responsible for evaluating the quality of literature and controlling academic viewpoints; Gu H is responsible for coordinating submissions, responding to review comments, and academic communication after publication. Zhang L assisted in data validation and chart creation; Gu WL participated in literature search, organization, and manuscript proofreading, providing support for research implementation and manuscript improvement. All authors have read and agreed to the final published version of the paper, confirming that the research process complies with academic ethical standards and has no conflicts of interest.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Hong Gu, Associate Chief Pharmacist, Department of Pharmacy, Jing
Received: November 14, 2025
Revised: December 16, 2025
Accepted: February 3, 2026
Published online: May 19, 2026
Processing time: 166 Days and 1.1 Hours
Revised: December 16, 2025
Accepted: February 3, 2026
Published online: May 19, 2026
Processing time: 166 Days and 1.1 Hours
Core Tip
Core Tip: This meta-analysis of five studies discussed the clinical efficacy of dopaminergic agents combined with selective serotonin reuptake inhibitors in the treatment of Parkinson’s disease with depressive disorder. The results showed that the ef