Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490 [DOI: 10.5498/wjp.v16.i4.115490]
Corresponding Author of This Article
Teng Ye, MD, Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Ouhai District, Wenzhou 325000, Zhejiang Province, China. andy325902@163.com
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Psychiatry
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Retrospective Study
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Apr 19, 2026 (publication date) through Mar 30, 2026
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Publication Name
World Journal of Psychiatry
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2220-3206
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490 [DOI: 10.5498/wjp.v16.i4.115490]
World J Psychiatry. Apr 19, 2026; 16(4): 115490 Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.115490
Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma
Shi Dong, Hui-Ling Mou, Hao Zhang, Teng Ye
Shi Dong, Hao Zhang, Department of Radiotherapy, Wenzhou Central Hospital, Wenzhou 325000, Zhejiang Province, China
Hui-Ling Mou, Teng Ye, Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Dong S conceived the study, curated and analysed the data, and drafted the original manuscript; Mou HL coordinated patient recruitment and assessment, refined the methodology, and critically revised the manuscript; Zhang H provided technical resources, performed the statistical analyses, and prepared all figures and tables; Ye T supervised the project, secured funding, and finalised the manuscript for submission; and all authors read and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Wenzhou Central Hospital (Approval No. 202508272142000006419). All procedures were performed in accordance with the ethical standards of the institutional and/or national research committee and with the Declaration of Helsinki.
Informed consent statement: Given the retrospective nature of the study, the requirement for obtaining written informed consent from individual patients was waived by the ethics committee.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: De-identified data underlying this article are available from the corresponding author upon reasonable request and with permission from the Wenzhou Central Hospital.
Corresponding author: Teng Ye, MD, Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Ouhai District, Wenzhou 325000, Zhejiang Province, China. andy325902@163.com
Received: November 4, 2025 Revised: December 8, 2025 Accepted: December 26, 2025 Published online: April 19, 2026 Processing time: 146 Days and 0.5 Hours
Core Tip
Core Tip: This retrospective study revealed that over half of malignant melanoma patients experienced depressive symptoms, which were closely associated with suppressed cellular immunity and elevated inflammatory markers such as interleukin-6 (IL-6) and neutrophil-to-lymphocyte ratio. CD4+ T cell count and serum albumin were found to be protective factors, while IL-6 and advanced tumor-node-metastasis stage were risk predictors. A multi-indicator model combining IL-6, CD4+, and neutrophil-to-lymphocyte ratio achieved good predictive performance (area under the curve = 0.834). These findings highlight the need for integrated psychosocial and immunological assessment in melanoma patients to improve mental health and potentially affect prognosis.
