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Observational Study
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World J Psychiatry. Mar 19, 2026; 16(3): 111988
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.111988
Resilience levels, associated factors, and their correlation with serum neurotransmitter levels in patients with gastric cancer
Neng Shen, Heng-Ke Wu, Xue-Mei Huang
Neng Shen, Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing 400030, China
Heng-Ke Wu, Oncology Treatment Center of Traditional Chinese Medicine, Chongqing University Cancer Hospital, Chongqing 400030, China
Xue-Mei Huang, Department of Clinical Laboratory, Chongqing University Cancer Hospital, Chongqing 400030, China
Co-first authors: Neng Shen and Heng-Ke Wu.
Author contributions: Shen N and Wu HK designed the research and wrote the first manuscript, conducted the analysis and provided guidance for the research, and they contributed equally to this manuscript and are co-first authors; Shen N, Wu HK and Huang XM contributed to conceiving the research and analyzing data. All authors reviewed and approved the final manuscript.
Institutional review board statement: The study was approved by the Institutional Review Board of Chongqing University Cancer Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Xue-Mei Huang, Department of Clinical Laboratory, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400030, China. 661203@cqu.edu.cn
Received: September 3, 2025
Revised: October 23, 2025
Accepted: December 12, 2025
Published online: March 19, 2026
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Core Tip

Core Tip: Being a prevalent malignancy, gastric cancer (GC) poses a great threat to patients’ physical and mental health. Despite the presence of extensive research on resilience’s psychological impact, insufficient evidence is available regarding its determinants in GC, with limited theoretical and variable inclusion frameworks. This investigation clarifies the variation in neurotransmitters between GC patients and healthy controls to elucidate how altered neurotransmitter levels influence patients’ resilience, while also identifying resilience-related determinants.