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Randomized Controlled Trial
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Feb 19, 2026; 16(2): 113734
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113734
Effect of multidisciplinary closed-loop care on pregnancy outcomes in anxiety and depression
Tian-Tian Shen, Ya-Juan Zhang, Qiu-Xia Xie
Tian-Tian Shen, Qiu-Xia Xie, Department of Obstetrics and Gynecology, Songjiang Maternal and Child Health Hospital of Shanghai, Shanghai 201620, China
Ya-Juan Zhang, Department of General Medicine, Pingjiang Xincheng Community Health Service Center, Suzhou 215008, Jiangsu Province, China
Author contributions: Shen TT, Xie QX, and Zhang YJ contributed to this work; Shen TT conceived and designed the study; Zhang YJ contributed to the discussion and manuscript design; Shen TT and Xie QX wrote, edited the manuscript, and reviewed the literature.
Supported by the Shanghai Songjiang District Science and Technology Research Project, No. 2023SJKJGG89.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Songjiang District Maternal and Child Health Hospital in Shanghai (approval No. 20230728).
Clinical trial registration statement: This study has not yet been registered with clinical trials.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No other data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiu-Xia Xie, MD, Associate Chief Pharmacist, Department of Obstetrics and Gynecology, Songjiang Maternal and Child Health Hospital of Shanghai, No. 1010 Xilin North Road, Songiang District, Shanghai 201620, China. xieqiuxia_2025@163.com
Received: September 3, 2025
Revised: October 8, 2025
Accepted: November 13, 2025
Published online: February 19, 2026
Processing time: 148 Days and 22.3 Hours
Core Tip

Core Tip: This pioneering study establishes a multidisciplinary closed-loop psychological intervention model for pregnant women with psychological dysfunction. Key findings demonstrate: 31.7% cesarean rate (vs 44.2% in controls; P < 0.05); 50% reduction in adverse maternal outcomes (15% vs 32.5%; P < 0.01); Improved postpartum pelvic floor recovery (dynamic electromyography activity increase, P < 0.05). The model integrates obstetric, psychological, and nutritional expertise through a “screening-intervention-feedback” loop, providing class A evidence for perinatal mental health guidelines.