Shen TT, Zhang YJ, Xie QX. Effect of multidisciplinary closed-loop care on pregnancy outcomes in anxiety and depression. World J Psychiatry 2026; 16(2): 113734 [DOI: 10.5498/wjp.v16.i2.113734]
Corresponding Author of This Article
Qiu-Xia Xie, MD, Associate Chief Pharmacist, Department of Obstetrics and Gynecology, Songjiang Maternal and Child Health Hospital of Shanghai, No. 1010 Xilin North Road, Songiang District, Shanghai 201620, China. xieqiuxia_2025@163.com
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Obstetrics & Gynecology
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Randomized Controlled Trial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 19, 2026 (publication date) through Feb 2, 2026
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World Journal of Psychiatry
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2220-3206
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Shen TT, Zhang YJ, Xie QX. Effect of multidisciplinary closed-loop care on pregnancy outcomes in anxiety and depression. World J Psychiatry 2026; 16(2): 113734 [DOI: 10.5498/wjp.v16.i2.113734]
World J Psychiatry. Feb 19, 2026; 16(2): 113734 Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113734
Effect of multidisciplinary closed-loop care on pregnancy outcomes in anxiety and depression
Tian-Tian Shen, Ya-Juan Zhang, Qiu-Xia Xie
Tian-Tian Shen, Qiu-Xia Xie, Department of Obstetrics and Gynecology, Songjiang Maternal and Child Health Hospital of Shanghai, Shanghai 201620, China
Ya-Juan Zhang, Department of General Medicine, Pingjiang Xincheng Community Health Service Center, Suzhou 215008, Jiangsu Province, China
Author contributions: Shen TT, Xie QX, and Zhang YJ contributed to this work; Shen TT conceived and designed the study; Zhang YJ contributed to the discussion and manuscript design; Shen TT and Xie QX wrote, edited the manuscript, and reviewed the literature.
Supported by the Shanghai Songjiang District Science and Technology Research Project, No. 2023SJKJGG89.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Songjiang District Maternal and Child Health Hospital in Shanghai (approval No. 20230728).
Clinical trial registration statement: This study has not yet been registered with clinical trials.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No other data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiu-Xia Xie, MD, Associate Chief Pharmacist, Department of Obstetrics and Gynecology, Songjiang Maternal and Child Health Hospital of Shanghai, No. 1010 Xilin North Road, Songiang District, Shanghai 201620, China. xieqiuxia_2025@163.com
Received: September 3, 2025 Revised: October 8, 2025 Accepted: November 13, 2025 Published online: February 19, 2026 Processing time: 148 Days and 22.3 Hours
Abstract
BACKGROUND
Perinatal anxiety and depression are prevalent conditions associated with significant health risks. Investigating the efficacy of a multidisciplinary approach combined with a closed-loop psychological intervention is essential for improving related outcomes.
AIM
To evaluate the clinical value of a multidisciplinary closed-loop intervention in improving pregnancy outcomes and promoting postpartum recovery in pregnant women with anxiety and depression.
METHODS
We conducted a randomized controlled trial involving 240 pregnant women with anxiety and depressive symptoms who received regular prenatal care at Shanghai Songjiang Maternal and Child Health Hospital between January 2024 and January 2025. Participants were randomized to an intervention group (multidisciplinary closed-loop intervention) or a control group (routine care). Delivery outcomes, maternal and neonatal complications, and postpartum pelvic floor function were compared.
RESULTS
The intervention group exhibited significantly lower rates of cesarean section (31.7% vs 44.2%, P < 0.05), adverse maternal outcomes (15% vs 32.5%, P < 0.01), and adverse neonatal outcomes (6.7% vs 15.8%, P < 0.05). Additionally, the intervention group demonstrated higher rates of normal labor progression (96.3% vs 86.5%, P < 0.05) and intact perineum (50.0% vs 32.8%, P < 0.05), alongside superior pelvic floor muscle recovery.
CONCLUSION
This integrated multidisciplinary closed-loop intervention model effectively improves maternal and infant outcomes and enhanced postpartum recovery in women experiencing perinatal anxiety and depression.
Core Tip: This pioneering study establishes a multidisciplinary closed-loop psychological intervention model for pregnant women with psychological dysfunction. Key findings demonstrate: 31.7% cesarean rate (vs 44.2% in controls; P < 0.05); 50% reduction in adverse maternal outcomes (15% vs 32.5%; P < 0.01); Improved postpartum pelvic floor recovery (dynamic electromyography activity increase, P < 0.05). The model integrates obstetric, psychological, and nutritional expertise through a “screening-intervention-feedback” loop, providing class A evidence for perinatal mental health guidelines.
