Zhang YM, Zhang ZG. Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders. World J Psychiatry 2025; 15(9): 108382 [DOI: 10.5498/wjp.v15.i9.108382]
Corresponding Author of This Article
Zhi-Gang Zhang, MD, Doctor, General Practice Clinic Ward, Second Department of The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. m18098875906@163.com
Research Domain of This Article
Psychology, Clinical
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Sep 19, 2025; 15(9): 108382 Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.108382
Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders
Yi-Ming Zhang, Zhi-Gang Zhang
Yi-Ming Zhang, Gastroenterology Clinic Ward, First Department of The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Zhi-Gang Zhang, General Practice Clinic Ward, Second Department of The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Author contributions: Zhang YM conceived and designed the study, performed the statistical analysis, and wrote the manuscript; Zhang ZG collected and processed the data, conducted literature research, and critically revised the manuscript for important intellectual content; Both authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Gang Zhang, MD, Doctor, General Practice Clinic Ward, Second Department of The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. m18098875906@163.com
Received: May 9, 2025 Revised: June 12, 2025 Accepted: July 17, 2025 Published online: September 19, 2025 Processing time: 109 Days and 2.7 Hours
Core Tip
Core Tip: This study explores the critical role of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in mitigating liver-brain axis dysfunction. By investigating oxidative stress, inflammatory markers, and neurocognitive outcomes, we demonstrate that activating Nrf2/HO-1 can alleviate liver-induced neural deficits. Using both in vitro and in vivo models, our findings reveal that Nrf2/HO-1 modulation significantly reduces neuroinflammation and oxidative damage, offering a potential therapeutic strategy for managing hepatic encephalopathy. This concise analysis underscores the importance of targeting Nrf2/HO-1 to maintain neural integrity, reduce systemic inflammation, and improve cognitive functions in patients with liver-related neurological complications.
