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World J Psychiatry. Dec 19, 2025; 15(12): 110290
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.110290
Anxiety disorders following percutaneous coronary intervention for acute myocardial infarction: A comprehensive review of clinical manifestations and interventions
Xin Tang, Gan Liu, Yun-Jie Zeng
Xin Tang, Department of Cardiovascular Medicine, People's Hospital of Chongqing Hechuan, Chongqing 401520, China
Gan Liu, Department of General Practice, People's Hospital of Chongqing Hechuan, Chongqing 401520, China
Yun-Jie Zeng, Department of Cardiovascular Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing 402360, China
Author contributions: Xin T and Gan L contributed equally to this work and were responsible for the literature search, data extraction, analysis, and manuscript drafting; Zeng YJ supervised the project, provided clinical expertise, and critically revised the manuscript; all the authors approved the final version and agree to be accountable for the work.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Jie Zeng, MD, Department of Cardiovascular Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, No. 1073 Second Ring South Road, Tangxiang Street, Dazu District, Chongqing 402360, China. zengyunjie@hospital.cqmu.edu.cn
Received: June 27, 2025
Revised: July 30, 2025
Accepted: September 16, 2025
Published online: December 19, 2025
Processing time: 153 Days and 1.6 Hours
Core Tip

Core Tip: Following percutaneous coronary intervention (PCI) for acute myocardial infarction, 20%-40% of patients suffer from anxiety disorders, which have a substantial negative influence on cardiovascular outcomes, medication adherence, and rehabilitation. The molecular mechanisms, sex-specific patterns, clinical manifestations, and temporal trajectories of post-PCI anxiety are highlighted in this review. Additionally, it assesses integrated cardiac rehabilitation programs, pharmaceutical treatments, psychological therapies (particularly cardiac-specific cognitive behavioral therapy), and evidence-based screening instruments. For this susceptible group, a multidisciplinary, individualized strategy that includes timely screening, focused intervention, and long-term follow-up is necessary to enhance both psychological health and cardiovascular prognosis.