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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2025; 15(10): 109293
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.109293
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.109293
Suicide attempt predictors among adolescents exhibiting non-suicidal self-injury: A six-week follow-up open study
Bing-Long Wen, Li-Na Zhou, Ya-Juan Fan, Ce Chen, Qing-Yan Ma, Xian-Cang Ma, Cheng-Ge Gao, Wei Wang, Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong Uni
Chun-Juan Yang, Department of Psychiatry and Psychology, Hanzhong Psychiatric Hospital, Hanzhong 723099, Shaanxi Province, China
Co-first authors: Bing-Long Wen and Chun-Juan Yang.
Author contributions: Wen BL, Yang CJ, and Zhou LN conceived this project; Fan YJ and Gao CG collected and analyzed the data; Yang CJ and Zhou LN wrote the initial draft of the manuscript; Wen BL, Chen C, Ma QY, Ma XC, and Wang W provided expert advice and revised the manuscript. Wen BL and Yang CJ contributed equally to this manuscript as co-first authors. All the authors contributed to this study and approved the submitted version.
Supported by the Natural Science Basic Research Program of Shaanxi Province, No. 2022SF526 and No. 2022SF509; and the National Natural Science Foundation of China, No. 82301737.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Xi'an Jiaotong University (Approval No. XJTU1AF2022 LSK-171).
Informed consent statement: Written informed consent was obtained from legal guardians, while adolescent participants provided written assent after demonstrating comprehension through age-appropriate explanation and verbal confirmation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Yanta District, Xi'an 710061, Shaanxi Province, China. xianwv@sina.com
Received: May 7, 2025
Revised: June 18, 2025
Accepted: August 13, 2025
Published online: October 19, 2025
Processing time: 142 Days and 18.5 Hours
Revised: June 18, 2025
Accepted: August 13, 2025
Published online: October 19, 2025
Processing time: 142 Days and 18.5 Hours
Core Tip
Core Tip: This observational study explores the link between inflammatory markers and suicide risk in Chinese adolescents with non-suicidal self-injury, alongside antidepressant treatment effects. Key findings reveal distinct inflammatory profiles stratified by suicide risk levels, with specific cytokines correlating to risk severity. Critically, antidepressant intervention modulates inflammatory expression while improving clinical symptoms. The study identifies a potential inflammatory biomarker for suicide risk assessment in non-suicidal self-injury adolescents, offering a novel biological perspective for clinical risk stratification and treatment monitoring.