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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2025; 15(10): 107123
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.107123
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.107123
Roles of genetic and environmental factors in psychiatric comorbidities among children with neurodevelopmental delays
Lin Li, Li-Juan Song, Xiao-Li Liu, Zhen-Fang Wang, Department of Rehabilitation, Children’s Hospital of Shanxi Province, Taiyuan 030013, Shanxi Province, China
Author contributions: Li L contributed to the statistical analysis and interpretation of the results; Song LJ was responsible for conducting the genetic testing and coordinating the environmental exposure assessments; Liu XL led the study implementation, including data collection and analysis; Song LJ and Liu XL contributed equally to the conceptualization, study design, and overall supervision of the research; Wang ZF provided critical input on the clinical aspects of the study and helped draft the manuscript; and all authors contributed to the writing, review, and final approval of the manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shanxi Children’s Hospital, approval No. IRB-2023-014.
Informed consent statement: This study was approved by the guardians of the patients.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No available data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Fang Wang, MD, Department of Rehabilitation, Children’s Hospital of Shanxi Province, No. 13 Xinmin North Street, Xinghualing District, Taiyuan 030013, Shanxi Province, China. w13834536398@yeah.net
Received: May 20, 2025
Revised: June 18, 2025
Accepted: August 4, 2025
Published online: October 19, 2025
Processing time: 128 Days and 23.2 Hours
Revised: June 18, 2025
Accepted: August 4, 2025
Published online: October 19, 2025
Processing time: 128 Days and 23.2 Hours
Core Tip
Core Tip: This study highlights the significant roles of both genetic and environmental factors in the development of psychiatric comorbidities among children with neurodevelopmental delays. Key findings include the identification of specific genetic variants associated with disorders such as attention-deficit/hyperactivity disorder and anxiety, as well as the influence of environmental stressors, including prenatal maternal stress and early childhood adversity. The complex interactions between genes and the environment underscore the need for integrated assessment approaches and targeted interventions to improve outcomes in this vulnerable population.