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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2025; 15(10): 105932
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.105932
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.105932
Effect of lurasidone plus sulpiride on treatment efficacy, psychiatric manifestations, and quality of life among patients with schizophrenia
Jing-Jing Zhao, Chong-Yang Han, Guo-Xin Xu, Min Zhou, Zhu-Ma Jin, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Co-first authors: Jing-Jing Zhao and Chong-Yang Han.
Author contributions: Zhao JJ and Han CY performed the study conceptualization and design, statistical analyses, data quality assessment and manuscript preparation, drafted the initial manuscript, and reviewed and revised the paper as the co-first authors; Xu GX and Zhou M contributed to the data acquisition; Jin ZM contributed to the data interpretation; All authors have read and agreed to the published version of the manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of The Affiliated Brain Hospital of Nanjing Medical University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The data analyzed in this study is available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhu-Ma Jin, Associate Chief Physician, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. jinzhumamiya@163.com
Received: May 20, 2025
Revised: July 2, 2025
Accepted: July 21, 2025
Published online: October 19, 2025
Processing time: 128 Days and 23.6 Hours
Revised: July 2, 2025
Accepted: July 21, 2025
Published online: October 19, 2025
Processing time: 128 Days and 23.6 Hours
Core Tip
Core Tip: Although first-generation antipsychotics have limited effectiveness against the negative symptoms of schizophrenia, sulpiride combined with lurasidone may offer superior results. This study suggests that, compared with sulpiride monotherapy, the combined approach enhances treatment efficacy safely, with patients experiencing fewer psychiatric symptoms, improved cognitive and social functioning, and better quality of life. It also helps normalize abnormal levels of interleukin 6 (IL-6), IL-17, and prolactin.