Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.110880
Revised: August 26, 2025
Accepted: November 12, 2025
Published online: February 19, 2026
Processing time: 184 Days and 22.8 Hours
Depression and insomnia are highly prevalent mental disorders with a significant comorbidity rate, each exacerbating the severity and course of the other in a bidirectional relationship. Current clinical interventions, including pharmacotherapy and traditional cognitive-behavioral therapy, primarily focus on alle
To explore the effect of PERMA theory-based cognitive intervention on depressive mood, sleep quality and quality of life in patients with depression complicated with insomnia.
A total of 106 patients with depression combined with insomnia who received treatment in Ganzhou People’s Hospital from January 2022 to January 2024 were selected for the study. According to the blind selection method, 106 patients were evenly divided into the control group and the observation group. The control group received conventional cognitive intervention, and the observation group was based on the PERMA theory. After 2 months of continuous intervention in both groups, the following were assessed: depression severity (17-item Hamilton Depression Scale, Self-rating Dep
Following the intervention, the observation group demonstrated significantly reduced scores on both the 17-item Hamilton Depression Scale (9.41 ± 2.80) and Self-rating Depression Scale (44.25 ± 2.71) compared with the control group (P < 0.05). All domain scores and the total score of the Pittsburgh Sleep Quality Index were markedly lower after treatment in the observation group than in the control group (P < 0.05). After intervention, the Repeatable Battery for the Assessment of Neuropsychological Status scores in the observation group (160.21 ± 15.17) were significantly higher than those in the control group (145.69 ± 12.58) (P < 0.05). After intervention, the observation group had a significantly higher total score on the Chinese version of the Personal and Social Functioning Scale (70.86 ± 6.92) compared with the control group (60.14 ± 11.52) (P < 0.05). Similarly, the observation group demon
PERMA-based cognitive intervention demonstrates superior effectiveness in patients with depression and como
Core Tip: This randomized controlled trial demonstrates that cognitive intervention based on the Positive Emotion, En
