Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders: Present trends and future directions
Bo-Fan Chen, Li Liu, Fang-Zhen Lin, Hai-Min Zeng, Hai-Qiang Huang, Chun-Fang Zhang, Cong-Cong Liu, Xiang Chen, Jie Peng, Yun-Fa Wang, Zhi-Lin Wang, Bin Chen, De-Le Liu, Yun Liu, Zheng-Zheng Li, Xin-Xing Zeng
Bo-Fan Chen, Li Liu, Fang-Zhen Lin, Hai-Min Zeng, Hai-Qiang Huang, Chun-Fang Zhang, Cong-Cong Liu, Jie Peng, Yun-Fa Wang, Zhi-Lin Wang, Bin Chen, Zheng-Zheng Li, Xin-Xing Zeng, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Bo-Fan Chen, Li Liu, Fang-Zhen Lin, Hai-Min Zeng, Hai-Qiang Huang, Chun-Fang Zhang, Cong-Cong Liu, Jie Peng, Yun-Fa Wang, Zhi-Lin Wang, Bin Chen, Zheng-Zheng Li, Xin-Xing Zeng, The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Xiang Chen, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
De-Le Liu, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi Province, China
Yun Liu, Department of Psychiatry, Jiangxi Mental Hospital, Hospital of Nanchang University, Nanchang University, Nanchang 330029, Jiangxi Province, China
Author contributions: Chen BF generated the conception; Chen BF, Liu L, Lin FZ, Zeng HM, Huang HQ, Zhang CF, and Liu CC investigated and analyzed data, and prepared the draft; Chen X and Peng J oversaw project administration and software; Wang YF, Wang ZL, and Chen B were responsible for funding acquisition and reviewed the draft; Liu DL, Liu Y, Li ZZ, and Zeng XX supervised the study and reviewed and edited the manuscript; and all authors contributed to the study’s conception and design, and read and approved the final manuscript.
Supported by the National College Students’ Innovative Entrepreneurial Training Plan Program, No. 202410403067; and the Innovation and Entrepreneurship Training Program for College Students in Jiangxi Province, No. S202410403035.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xin-Xing Zeng, The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, No. 1299 Xuefu Avenue, Xinjian County, Honggutan District, Nanchang 330006, Jiangxi Province, China.
18679166679@163.com
Received: August 23, 2024
Revised: October 28, 2024
Accepted: November 26, 2024
Published online: January 19, 2025
Processing time: 117 Days and 8 Hours
BACKGROUND
Bipolar disorder (BD) is a severe mental illness characterized by significant mood swings. Effective drug treatment modalities are crucial for managing BD.
AIM
To analyze the current status and future trends of global research on BD drug treatment over the last decade.
METHODS
The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment. A total of 2624 articles were extracted. Data visualization and analysis were conducted using CiteSpace, VOSviewer, Pajek, Scimago Graphica, and R-studio bibliometrix to identify research hotspots, key contributors, and future trends.
RESULTS
The United States, China, and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks. The University of Pittsburgh, Massachusetts General Hospital, and the University of Michigan have been identified as the major research institutions in this field. The Journal of Affective Disorders is the most influential journal. A keyword analysis revealed research hotspots related to clinical symptoms, drug efficacy, and genetic mechanisms. A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.
CONCLUSION
This study provides a detailed overview of the field of BD drug treatment, highlighting key contributors, research hotspots, and future directions. The study findings can be employed as a reference for future research and policymaking, which may enable further development and optimization of BD pharmacotherapy.
Core Tip: This study employs advanced bibliometric tools, including CiteSpace, VOSviewer, and the bibliometrix package in R, to analyze the evolution of pharmacotherapy for bipolar disorder over the past decade. It identifies key contributors, research hotspots, and future trends, emphasizing significant international collaborations, particularly among institutions in the United States, China, and the United Kingdom. The findings highlight key areas such as clinical symptoms, drug efficacy, and genetic mechanisms, providing valuable insights for scholars and policymakers. This work offers clear guidance for innovation in bipolar disorder pharmacotherapy and serves as a critical reference for future research.
