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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 9, 2025; 14(4): 107570
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.107570
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.107570
Stroke metrics, safety, and outcomes of telemedicine-administered thrombolytics for acute ischemic stroke: A meta-analysis
Andrea Loggini, Jonatan Hornik, Alejandro Hornik, Brain and Spine Institute, Southern Illinois Healthcare, Carbondale, IL 62901, United States
Andrea Loggini, Amber Schwertman, Department of Neurology, Southern Illinois University School of Medicine, Carbondale, IL 62901, United States
Karam Dallow, Department of Neurology, Southern Illinois University, Carbondale, IL 62901, United States
Author contributions: Loggini A was responsible for study concept, study design, data abstraction, data analysis, and drafting the manuscript; Schwertman A and Dallow K were responsible for data abstraction and data analysis; Hornik J was responsible for study design, data abstraction, data analysis, and drafting the manuscript; Hornik A was responsible for critical revision and approval of the final version of the manuscript.
Conflict-of-interest statement: None of the authors has any conflict of interest or financial disclosures to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrea Loggini, MD, MBA, Adjunct Assistant Professor, Brain and Spine Institute, Southern Illinois Healthcare, 405 W Jackson Street, Carbondale, IL 62901, United States. andrea.loggini@sih.net
Received: March 26, 2025
Revised: April 11, 2025
Accepted: May 27, 2025
Published online: December 9, 2025
Processing time: 247 Days and 21.4 Hours
Revised: April 11, 2025
Accepted: May 27, 2025
Published online: December 9, 2025
Processing time: 247 Days and 21.4 Hours
Core Tip
Core Tip: In this meta-analysis, we compared telemedicine technology to in-person evaluation for the treatment of acute ischemic stroke, highlighting the differences in door-to-needle time (DTN) between the two modalities, and the impact of them on outcomes. The literature suggests that the stroke metric, in terms of DTN, is longer by telemedicine modality of evaluation. However, this difference does not translate in differences in safety and outcomes.