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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Dec 18, 2025; 16(12): 110377
Published online Dec 18, 2025. doi: 10.5312/wjo.v16.i12.110377
Published online Dec 18, 2025. doi: 10.5312/wjo.v16.i12.110377
Platelet rich plasma applications in orthopedics: A review of recent advances
Arnav Pankaj Rathod, Yogesh Rathod, Rajendra Baitule, Ganesh Pundkar, Hrishikesh Saodekar, Department of Orthopedics, Dr. Panjabrao Deshmukh Memorial Medical College and Hospital, Amravati 444602, Mahārāshtra, India
Co-corresponding authors: Arnav Pankaj Rathod and Yogesh Rathod.
Author contributions: Rathod AP, Rathod Y contributed to conception and design of the study, acquisition of data, analysis and interpretation of data, drafting or revising the manuscript, final approval of the version to be published; Baitule R, Pundkar G, Saodekar H contributed to analysis and interpretation of data, drafting or revising the manuscript, final approval of the version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arnav Pankaj Rathod, Academic Fellow, Department of Orthopedics, Dr. Panjabrao Deshmukh Memorial Medical College and Hospital, Flat No. 412, 4th Floor, Amravati 444601, Mahārāshtra, India. rarnav95@yahoo.in
Received: June 9, 2025
Revised: August 8, 2025
Accepted: October 22, 2025
Published online: December 18, 2025
Processing time: 192 Days and 21.4 Hours
Revised: August 8, 2025
Accepted: October 22, 2025
Published online: December 18, 2025
Processing time: 192 Days and 21.4 Hours
Core Tip
Core Tip: Recent advancements have firmly established platelet-rich plasma (PRP) therapy as a valuable tool in orthopedic care. Innovations such as protein-enriched filtered PRP, integration with 3D-printed scaffolds, and combination therapies with mesenchymal stem cells and peptides have enhanced its regenerative potential. These developments have expanded PRP applications beyond sports medicine to include osteoarthritis, tendinopathies, and cartilage defects. While PRP offers promising outcomes, standardization of preparation methods and further large-scale clinical trials are essential to optimize its efficacy and establish comprehensive clinical guidelines.