Rathod AP, Rathod Y, Baitule R, Pundkar G, Saodekar H. Platelet rich plasma applications in orthopedics: A review of recent advances. World J Orthop 2025; 16(12): 110377 [DOI: 10.5312/wjo.v16.i12.110377]
Corresponding Author of This Article
Arnav Pankaj Rathod, Academic Fellow, Department of Orthopedics, Dr. Panjabrao Deshmukh Memorial Medical College and Hospital, Flat No. 412, 4th Floor, Amravati 444601, Mahārāshtra, India. rarnav95@yahoo.in
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 18, 2025 (publication date) through Dec 17, 2025
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Journal Information of This Article
Publication Name
World Journal of Orthopedics
ISSN
2218-5836
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Rathod AP, Rathod Y, Baitule R, Pundkar G, Saodekar H. Platelet rich plasma applications in orthopedics: A review of recent advances. World J Orthop 2025; 16(12): 110377 [DOI: 10.5312/wjo.v16.i12.110377]
Arnav Pankaj Rathod, Yogesh Rathod, Rajendra Baitule, Ganesh Pundkar, Hrishikesh Saodekar, Department of Orthopedics, Dr. Panjabrao Deshmukh Memorial Medical College and Hospital, Amravati 444602, Mahārāshtra, India
Co-corresponding authors: Arnav Pankaj Rathod and Yogesh Rathod.
Author contributions: Rathod AP, Rathod Y contributed to conception and design of the study, acquisition of data, analysis and interpretation of data, drafting or revising the manuscript, final approval of the version to be published; Baitule R, Pundkar G, Saodekar H contributed to analysis and interpretation of data, drafting or revising the manuscript, final approval of the version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arnav Pankaj Rathod, Academic Fellow, Department of Orthopedics, Dr. Panjabrao Deshmukh Memorial Medical College and Hospital, Flat No. 412, 4th Floor, Amravati 444601, Mahārāshtra, India. rarnav95@yahoo.in
Received: June 9, 2025 Revised: August 8, 2025 Accepted: October 22, 2025 Published online: December 18, 2025 Processing time: 192 Days and 21.4 Hours
Abstract
Platelet-rich plasma (PRP) therapy has gained prominence in orthopedics as a regenerative approach that utilizes autologous platelets enriched with growth factors to facilitate tissue healing. Innovations such as protein-enriched filtered PRP and the integration of PRP with biomaterials, including 3D-printed scaffolds and bioactive molecules like kartogenin, have been developed to enhance outcomes in cartilage and bone repair. Clinical studies have demonstrated the efficacy of PRP in managing conditions such as knee osteoarthritis, rotator cuff tendinopathy, and lateral epicondylitis, often showing superior long-term benefits compared with conventional treatments. Emerging therapies that combine PRP with mesenchymal stem cells and peptide-based treatments have shown synergistic effects, further enhancing tissue regeneration and functional recovery. Despite these promising developments, variability in PRP preparation methods and application protocols underscores the need for standardized guidelines and large-scale clinical trials to fully establish the role of PRP in orthopedic practice.
Core Tip: Recent advancements have firmly established platelet-rich plasma (PRP) therapy as a valuable tool in orthopedic care. Innovations such as protein-enriched filtered PRP, integration with 3D-printed scaffolds, and combination therapies with mesenchymal stem cells and peptides have enhanced its regenerative potential. These developments have expanded PRP applications beyond sports medicine to include osteoarthritis, tendinopathies, and cartilage defects. While PRP offers promising outcomes, standardization of preparation methods and further large-scale clinical trials are essential to optimize its efficacy and establish comprehensive clinical guidelines.
