ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role

Table 1 Expression of KLK10 in some types of cancers

Cancer	Expression of KLK10 in the tumor compared with non-tumor conditions	Ref.
Breast cancer	Expression depends on stage, grade, and metastasis	[37,44,46-48]
Gastric cancer	Expression depends on stage, grade, and metastasis	[42,49,94]
Prostate cancer	Decreased	[37,38]
Esophageal cancer	Decreased	[52]
Acute lymphoblastic leukemia	Decreased	[40,41]
Testicular cancer	Decreased	[95]
Ovarian cancer	Decreased	[37]
Cutaneous melanoma	Increased	[55]
Colorectal cancer	Increased	[50,51]
Colon cancer	Increased	[96]
Pancreatic cancer	Increased	[53,54]

Table 2 Expression of KLK5 in some types of cancer

Cancer	Expression of KLK5 in the tumor compared with non-tumor conditions	Ref.
Breast cancer	Expression depends on stage, grade, and metastasis	[65,66,70,74]
Oral squamous cell carcinoma	Expression depends on stage, grade, and metastasis	[88,89,97]
Vaginal carcinogenesis	Decreased	[34]
Prostate cancer	Decreased	[35]
Testicular cancer	Decreased	[67]
Ovarian cancer	Increased	[77,68]
Skin tumorigenesis	Increased	[61]
Urinary bladder carcinoma cells	Increased	[84]
Uterine cervical cancer	Increased	[76]
Lung cancer	Increased	[83]
Gastric adenocarcinoma	Increased	[81]

Table 3 ADAM metallopeptidase with thrombospondin type 1 motif 8, kallikrein-related peptidases 10 and 5 in some human cancers

Cancer	Expression of ADAMTS-8	Expression of KLK10	Expression of KLK5
Breast cancer	1	1	1
Prostate cancer	-	-	2
Testicular cancer	-	2	2
Vaginal cancer	-	-	2
Ovarian cancer	-	2	3
Gastric cancer	2	1	3
Brain cancer	2	-	-
Lung cancer	2	2	-
Colorectal cancer	2	3	-
Esophageal squamous cell carcinoma	2	-	-
Hepatocellular carcinoma	2	-	-
Esophageal cancer	-	2	-
Acute lymphoblastic leukemia	-	2	-
Skin cancer	-	3	3
Colon cancer	-	3	-
Pancreatic cancer	-	3	-
Oral squamous cell carcinoma	-	-	1
Urinary bladder carcinoma cells	-	-	3

¹Indicates dual function.

²Indicates downregulation with function as a tumor suppressor.

³Indicates overexpression with protumoral properties.