Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions

doi:10.5306/wjco.v17.i2.115451

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Feb 24, 2026 (publication date) through Feb 12, 2026

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 24, 2026; 17(2): 115451
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.115451

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Figure 1 Dissection of the gamma chain cytokine family. IL: Interleukin; γc: Gamma chain; JAK: Janus kinase; STAT: Signal transducer and activator of transcription; NK: Natural killer; Th: T helper cell.

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Figure 2 Gamma chain cytokine-mediated chimeric antigen receptor T optimization strategies. MDSC: Myeloid-derived suppressor cell; TAM: Tumor-associated macrophage; PD-L1: Programmed death-ligand 1; CTLA-4: Cytotoxic T-lymphocyte-associated protein 4; LAG3: Lymphocyte activation gene 3; IL: Interleukin; TGF-β: Transforming growth factor-β; ECM: Extracellular matrix; CAF: Cancer-associated fibroblast; ROS: Reactive oxygen species; γc: Gamma chain; CAR-T: Chimeric antigen receptor T; PD-1: Programmed death-1; TME: Tumor microenvironment.

Citation: Zuo DB, Chen ZH, Jin YM, Sang M, Sun XD, Guo A, Li XY, Wu JX, Ji KK, Zhou H. Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions. World J Clin Oncol 2026; 17(2): 115451
URL: https://www.wjgnet.com/2218-4333/full/v17/i2/115451.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i2.115451