Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens

Figure 1 Patient selection process.

Figure 2 Correlation scatter plots stratified by Ferritin index quartiles. A: Survival; B: Survival time; C: Gender; D: Aspartate aminotransferase; E: Tumor-associated material; F: Tumor-supplied group of factor; G: Age; H: Alanine aminotransferase; I: Alkaline phosphatase; J: Lactate dehydrogenase; K: Gamma-glutamyl transferase; L: 5'-Nucleotidase; M: Glycyl-proline-dipeptidyl aminopeptidase; N: Adenosine deaminase; O: Monoamine oxidase; P: Neuron-specific enolase; Q: Carcinoembryonic antigen; R: Alpha-fetoprotein. Abscissa: Ferritin quartile 1 (1.89-83.13); Ferritin quartile 2 (83.18-129.21); Ferritin quartile 3 (130.65-175.25); Ferritin quartile 4 (175.68-378.29). R, Pearson correlation coefficient. AST: Aspartate aminotransferase; TAM: Tumor-associated material; TSGF: Tumor-supplied group of factor; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDH: Lactate dehydrogenase; GGT: Gamma-glutamyl transferase; 5-NT: 5'-Nucleotidase; GPDA: Glycyl-proline-dipeptidyl aminopeptidase; ADA: Adenosine deaminase; MAO: Monoamine oxidase; NSE: Neuron-specific enolase; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein.

Figure 3 Restricted cubic spline analysis of association between the Ferritin index and nasopharyngeal carcinoma mortality. A: Univariable analysis for 3-year mortality; B: Multivariable analysis for 3-year mortality after adjusting covariates.

Figure 4 Forest plots showing association between the Ferritin index and mortality in nasopharyngeal carcinoma patients. A: Univariable analysis for 5-year mortality; B: Univariable analysis for 3-year mortality. HR: Hazard ratio.

Figure 5 Kaplan-Meier survival analysis for mortality in nasopharyngeal carcinoma patients according to the Ferritin index. A: 5-year mortality; B: 3-year mortality.

Figure 6 Receiver operating characteristic curves of the Ferritin index as a marker to predict 5-year mortality. A: Training set; B: Validation set. AUC: Area under the curve.

Figure 7 Nomogram for predicting 5-year mortality in nasopharyngeal carcinoma patients according to Ferritin index quartiles. MAO: Monoamine oxidase.

Figure 8 Calibration curves of the Ferritin index as a marker to predict 5-year mortality. A: Training set; B: Validation set.

Figure 9 Decision curve analysis curves of the Ferritin index to predict 5-year mortality. A: Training set; B: Validation set.