Synchronous cholangiocarcinoma and cervical squamous cell carcinoma managed via a multidisciplinary approach: A case report

Figure 1 Evaluation of cervical lesions by histopathology. A: Liquid-based cytology reveals atypical squamous cells with nuclear enlargement, hyperchromasia, and a high nucleus-to-cytoplasm ratio, which is consistent with a high-grade squamous intraepithelial lesion (scale bar, 50 μm); B: Cervical biopsy reveals invasive squamous cell carcinoma with prominent nuclear atypia and stromal infiltration (scale bar, 100 μm).

Figure 2 Imaging findings of the cervical and hepatic lesions. A: Transvaginal ultrasound image showing a hypoechoic cervical mass with poorly defined margins and abundant blood flow (orange arrow); B: Contrast-enhanced computed tomography during the delayed phase showing a hypodense lesion (approximately 3 cm) in segment V of the liver with progressive peripheral enhancement, radiologically consistent with an American Joint Committee on Cancer 8^th T1a intrahepatic cholangiocarcinoma (orange arrow); C: Contrast-enhanced magnetic resonance image reveals a hyperintense lesion in segment V on T2-weighted imaging, suggesting malignancy (orange arrow); D: Positron emission tomography/computed tomography image showing intense fluorodeoxyglucose uptake in the same lesion, supporting the diagnosis of a metabolically active primary tumor (orange arrow).

Figure 3 Histopathological confirmation of intrahepatic cholangiocarcinoma. A: Ultrasound-guided liver biopsy specimen stained with hematoxylin and eosin shows irregular glandular structures with nuclear atypia, which is consistent with adenocarcinoma (scale bar, 200 μm). B: Postoperative resection revealed moderately differentiated intrahepatic cholangiocarcinoma with perineural invasion and dense fibrous stroma (scale bar, 50 μm).