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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2025; 16(9): 109644
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.109644
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.109644
Synchronous cholangiocarcinoma and cervical squamous cell carcinoma managed via a multidisciplinary approach: A case report
Zhi-Jian Wu, Bin Wang, Si-Cong Zhao, Zhan-Teng Pan, Department of Hepatobiliary Surgery, Dongyang People’s Hospital, Affiliated to Wenzhou Medical University, Dongyang 322100, Zhejiang Province, China
Co-first authors: Zhi-Jian Wu and Bin Wang.
Author contributions: Wu ZJ conceptualized the study, drafted the abstract, introduction, and case presentation sections, and conducted the literature review; Wang B led the study design, contributed to case management decisions, and supervised the manuscript preparation; Zhao SC contributed to the clinical discussion and provided critical intellectual input during the revision of key academic content; Pan ZT was responsible for data collection and analysis. Wu ZJ and Wang B contributed equally to this work and are co-first authors. All authors have read and approved the final version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jian Wu, MMed, Attending Surgeon, Department of Hepatobiliary Surgery, Dongyang People’s Hospital, Affiliated to Wenzhou Medical University, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. zhijian.wu.med@qq.com
Received: May 19, 2025
Revised: June 24, 2025
Accepted: August 20, 2025
Published online: September 24, 2025
Processing time: 129 Days and 15.3 Hours
Revised: June 24, 2025
Accepted: August 20, 2025
Published online: September 24, 2025
Processing time: 129 Days and 15.3 Hours
Core Tip
Core Tip: Synchronous primary cancers involving cholangiocarcinoma and cervical squamous cell carcinoma are extremely rare, posing significant diagnostic and therapeutic challenges. We report successful multidisciplinary management of such a case in a 74-year-old woman through combined laparoscopic liver resection, pelvic radiotherapy, targeted therapy, chemotherapy, and immunotherapy. At the 12-month follow-up, imaging and tumor marker data indicated no recurrence or metastasis. This case highlights the importance of personalized, multidisciplinary approaches in managing rare synchronous malignancies, providing valuable insights for clinicians encountering similar complex scenarios.