Wu ZJ, Wang B, Zhao SC, Pan ZT. Synchronous cholangiocarcinoma and cervical squamous cell carcinoma managed via a multidisciplinary approach: A case report. World J Clin Oncol 2025; 16(9): 109644 [PMID: 41024849 DOI: 10.5306/wjco.v16.i9.109644]
Corresponding Author of This Article
Zhi-Jian Wu, MMed, Attending Surgeon, Department of Hepatobiliary Surgery, Dongyang People’s Hospital, Affiliated to Wenzhou Medical University, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. zhijian.wu.med@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Sep 24, 2025; 16(9): 109644 Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.109644
Synchronous cholangiocarcinoma and cervical squamous cell carcinoma managed via a multidisciplinary approach: A case report
Zhi-Jian Wu, Bin Wang, Si-Cong Zhao, Zhan-Teng Pan
Zhi-Jian Wu, Bin Wang, Si-Cong Zhao, Zhan-Teng Pan, Department of Hepatobiliary Surgery, Dongyang People’s Hospital, Affiliated to Wenzhou Medical University, Dongyang 322100, Zhejiang Province, China
Co-first authors: Zhi-Jian Wu and Bin Wang.
Author contributions: Wu ZJ conceptualized the study, drafted the abstract, introduction, and case presentation sections, and conducted the literature review; Wang B led the study design, contributed to case management decisions, and supervised the manuscript preparation; Zhao SC contributed to the clinical discussion and provided critical intellectual input during the revision of key academic content; Pan ZT was responsible for data collection and analysis. Wu ZJ and Wang B contributed equally to this work and are co-first authors. All authors have read and approved the final version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jian Wu, MMed, Attending Surgeon, Department of Hepatobiliary Surgery, Dongyang People’s Hospital, Affiliated to Wenzhou Medical University, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. zhijian.wu.med@qq.com
Received: May 19, 2025 Revised: June 24, 2025 Accepted: August 20, 2025 Published online: September 24, 2025 Processing time: 129 Days and 15.3 Hours
Abstract
BACKGROUND
Multiple primary cancers refer to the presence of two or more distinct malignant tumors in a single individual, either simultaneously or sequentially. The synchronous occurrence of cholangiocarcinoma (CCA) and cervical squamous cell carcinoma (SCC) is extremely rare. This case highlights the diagnostic challenges and significance of a multidisciplinary team in managing complex malignancies involving both the hepatobiliary and gynecologic systems. The 8th edition of the American Joint Committee on Cancer staging system was as follows: T1aN0M0 intrahepatic CCA; the 2018 edition of the International Federation of Gynecology and Obstetrics staging system was stage IB1 cervical SCC.
CASE SUMMARY
A 74-year-old postmenopausal woman (Karnofsky performance status = 80) presented with a one-day history of vaginal bleeding. Cross-sectional imaging (contrast-enhanced computed tomography, liver magnetic resonance imaging, and positron emission tomography/computed tomography) first demonstrated a single 3-cm lesion in liver segment V and a hypermetabolic cervical mass. Subsequent ultrasound-guided liver biopsy confirmed CCA, whereas cervical biopsy revealed SCC. After multidisciplinary discussion, the patient underwent laparoscopic liver resection. Pelvic external-beam radiotherapy was delivered at 45 grays in 25 fractions (6-megavolt photons) over 5 weeks, followed by high-dose-rate 192Ir intracavitary brachytherapy, at 35 grays in 7 fractions (International Commission on Radiation Units and Measurements A-point). She received eight cycles of systemic therapy with lenvatinib, capecitabine, and camrelizumab. Over a 12-month follow-up, she remained disease-free with no signs of recurrence or metastasis.
CONCLUSION
Multidisciplinary management offers a promising strategy for treating synchronous complex malignancies with individualized treatment plans.
Core Tip: Synchronous primary cancers involving cholangiocarcinoma and cervical squamous cell carcinoma are extremely rare, posing significant diagnostic and therapeutic challenges. We report successful multidisciplinary management of such a case in a 74-year-old woman through combined laparoscopic liver resection, pelvic radiotherapy, targeted therapy, chemotherapy, and immunotherapy. At the 12-month follow-up, imaging and tumor marker data indicated no recurrence or metastasis. This case highlights the importance of personalized, multidisciplinary approaches in managing rare synchronous malignancies, providing valuable insights for clinicians encountering similar complex scenarios.
