Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration: A case report

Figure 1 Brain magnetic resonance imaging and immunohistochemical features. A-D: Hematoxylin and eosin and immunohistochemical staining of pathological sections from the patient: cytokeratin5/6 (+), P63 (+), β-catenin (+); E: Preoperative brain magnetic resonance imaging (MRI) image of the patient; F: Postoperative brain MRI; G: Brain MRI figure following radio and chemotherapy.

Figure 2 Bioinformatics analyses of the two risk variants. A: Analysis of the conservation of Gap junction protein beta 2 (GJB2): P86Thr and Toll-like receptor 2 (TLR2): P347Lys across species; B: Local depictions of the three-dimensional protein structure of GJB2 prior to and after mutation; C: Local depictions of the three-dimensional protein structure of TLR2 prior to and after mutation. Black boxes indicate the altered amino acid. GJB2: Gap junction protein beta 2; TLR2: Toll-like receptor 2.

Figure 3 The expression of Gap junction protein beta 2 and Toll-like receptor 2 in the GSE42256 dataset. A and B: Gap junction protein beta 2 and Toll-like receptor 2 were significantly over-expressed in the cholesteatoma group compared with normal population. GJB2: Gap junction protein beta 2; TLR2: Toll-like receptor 2.