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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 24, 2024; 15(11): 1428-1434
Published online Nov 24, 2024. doi: 10.5306/wjco.v15.i11.1428
Published online Nov 24, 2024. doi: 10.5306/wjco.v15.i11.1428
Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration: A case report
Zhao-Na Song, Yan Cheng, Xiao-Dong Jia, Joint Laboratory for Translational Medicine Research, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, China
Dan-Dan Wang, Zhen Liu, Xiao-Ru Zhu, Harbin Genars Technology Co., Ltd., Harbin 150060, Heilongjiang Province, China
Ming-Jun Li, Xiang-Rong Zhao, Yu-Fang Wang, Feng-Fan Liang, Department of Radiotherapy, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, China
Fa-Wang Li, Department of Medical laboratory, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou 253600, Shandong Province, China
Co-first authors: Zhao-Na Song and Yan Cheng.
Co-corresponding authors: Yu-Fang Wang and Feng-Fan Liang.
Author contributions: Song ZN and Cheng Y contributed to data analysis and writing of the manuscript; Li MJ, Zhao XR and Li FW contributed to data collection and interpretation; Wang DD, Liu Z and Zhu XR provided technical support; Liang FF, Wang YF and Jia XD contributed to study design and critical revision of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Informed consent statement: We obtained informed written consent from the patient to publish this case report and any accompanying Figures.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Fan Liang, Doctor, Attending Doctor, Department of Radio
Received: April 19, 2024
Revised: September 11, 2024
Accepted: September 25, 2024
Published online: November 24, 2024
Processing time: 177 Days and 22.9 Hours
Revised: September 11, 2024
Accepted: September 25, 2024
Published online: November 24, 2024
Processing time: 177 Days and 22.9 Hours
Core Tip
Core Tip: Intracranial epidermoid cyst (IEC) malignant transformation is an uncommon lesion, accompanied by the spread of tumor cells, resulting in a poor prognosis. In this report, we present the case of a 47-year-old woman who was diagnosed with a malignant transition from IEC to squamous cell carcinoma. After surgical resection and chemoradiotherapy, the patient's condition was effectively controlled. It's noteworthy that whole exome sequencing revealed the significant role of Gap junction protein beta 2 and Toll-like receptor 2 in IEC development.