Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Oncol. Mar 24, 2026; 17(3): 116673
Published online Mar 24, 2026. doi: 10.5306/wjco.v17.i3.116673
Published online Mar 24, 2026. doi: 10.5306/wjco.v17.i3.116673
Online adaptive radiotherapy enhances precision and outcomes in the treatment of cervical cancer
Guang-Yu Wang, Yi-Ning Chen, Shuai Sun, Ke Hu, Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Co-first authors: Guang-Yu Wang and Yi-Ning Chen.
Co-corresponding authors: Shuai Sun and Ke Hu.
Author contributions: Wang GY and Chen YN conducted the literature search, data extraction, evidence synthesis, and manuscript drafting, and they contributed equally to this work as co-first authors; Sun S and Hu K supervised the study, provided critical revision of the manuscript and ensured the accuracy and integrity of the content, and they contributed equally to this manuscript as co-corresponding authors. All authors have contributed to the manuscript and approved the final version for submission.
Supported by National High Level Hospital Clinical Research Funding, No. 2025-PUMCH-A-027; and National Key R and D Program of China, Ministry of Science and Technology of the People’s Republic of China, No. 2022YFC2402305.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Shuai Sun, MD, Professor, Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China. sunshuai@pumch.cn
Received: November 18, 2025
Revised: January 21, 2026
Accepted: February 27, 2026
Published online: March 24, 2026
Processing time: 126 Days and 0.7 Hours
Revised: January 21, 2026
Accepted: February 27, 2026
Published online: March 24, 2026
Processing time: 126 Days and 0.7 Hours
Core Tip
Core Tip: Online adaptive radiotherapy (oART) enables individualized, fraction-by-fraction plan adaptation in cervical cancer, addressing tumor regression, organ motion, and anatomic variability. By integrating daily imaging, automated or artificial intelligence-assisted contouring, and on-table plan re-optimization, oART improves target coverage, enhances dose precision, and effectively spares pelvic organs at risk. Evidence demonstrates that oART can reduce acute treatment-related toxicities and provides a practical framework for workflow optimization and clinical implementation in modern cervical cancer radiotherapy.