©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2026; 17(2): 113428
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.113428
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.113428
Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration
Vivian Zweig, Department of Biology, Washington University, Saint Louis, MO 63130, United States
Sanjay Goel, Division of Medical Oncology, RJW Barnabas Health, Rutgers Cancer Institute, New Brunswick, NJ 08901, United States
Radhashree Maitra, Department of Biology, Yeshiva University, New York, NY 10033, United States
Author contributions: Zweig V performed all the pathway analysis and comparison with the cytokine expression; Maitra R conceptualized and performed the RNA sequencing; Goel S evaluated the analysis, drafting, and revising of the article; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Albert Einstein College of Medicine, No. 10-02-037.
Informed consent statement: All patient blood samples were drawn with informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The authors have shared individual deidentified participant data in the public domain to be available indefinitely. These raw data include peripheral mononuclear cell samples at four timepoints (pre-treatment, 48 hours, day 8 and day 15) for each individual involved in the clinical trial. This data can be accessed through the NCBI GEO Accession Viewer (Series GSE173636) using the following URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE173636.
Corresponding author: Radhashree Maitra, Full Professor, Department of Biology, Yeshiva University, 500 W 185th Street, New York, NY 10033, United States.
Received: August 28, 2025
Revised: October 14, 2025
Accepted: January 4, 2026
Published online: February 24, 2026
Processing time: 165 Days and 4 Hours
Revised: October 14, 2025
Accepted: January 4, 2026
Published online: February 24, 2026
Processing time: 165 Days and 4 Hours
Core Tip
Core Tip: This study highlights the prospective of reovirus as both an immunomodulatory agent and a cytotoxic adjuvant to chemotherapy in patients with KRAS-mutant metastatic colorectal cancer. Reovirus induces anti-tumor immunity by mo