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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jan 24, 2026; 17(1): 113857
Published online Jan 24, 2026. doi: 10.5306/wjco.v17.i1.113857
Published online Jan 24, 2026. doi: 10.5306/wjco.v17.i1.113857
Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients
Shi-Qiong Zhou, Qing-Hua Ke, Department of Chemoradiotherapy, Jingzhou No. 1 People’s Hospital and First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Author contributions: Ke QH wrote the first draft, developed the main ideas, and led revisions; Zhou SQ provided critical feedback, improved the structure, and added key examples; and all authors approved the manuscript and its submission to the journal.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Hua Ke, PhD, Chief Physician, Department of Chemoradiotherapy, Jingzhou No. 1 People’s Hospital and First Affiliated Hospital of Yangtze University, No. 10 Tianhu Road, Shashi District, Jingzhou 434000, Hubei Province, China. 3803354759@qq.com
Received: September 5, 2025
Revised: September 27, 2025
Accepted: December 15, 2025
Published online: January 24, 2026
Processing time: 137 Days and 19.6 Hours
Revised: September 27, 2025
Accepted: December 15, 2025
Published online: January 24, 2026
Processing time: 137 Days and 19.6 Hours
Core Tip
Core Tip: This article explores early esophageal neoplastic lesions (low/high-grade intraepithelial neoplasia, early/superficial carcinoma) treated with endoscopic submucosal dissection, revealing heterogeneity in endoscopic/pathological features, curative resection rate, and prognosis. Key factors include non-curative resection, esophageal stricture, age, and prior cancer history. Biomarkers (Ki-67, p53) differ by lesion grade, correlating with invasion and treatment response, informing stratified management, adjuvant therapy, and personalized surveillance.