Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies

doi:10.5306/wjco.v16.i9.110686

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Sep 24, 2025 (publication date) through Mar 18, 2026

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Sep 24, 2025; 16(9): 110686
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.110686

Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies

Joseph Mercola

Joseph Mercola, Midwestern University, Downers Grove, IL 60515, United States

Author contributions: Mercola J was the sole author responsible for study conception and design, data acquisition and interpretation, manuscript preparation and revision, final approval of the version to be published, and agrees to be accountable for the integrity of the work in all respects.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Joseph Mercola, Researcher, Midwestern University, 555 31^st Street, Downers Grove, IL 60515, United States. drm@mercola.com

Received: June 12, 2025
Revised: July 14, 2025
Accepted: August 20, 2025
Published online: September 24, 2025
Processing time: 103 Days and 11.3 Hours

Core Tip

Core Tip: Industrial seed-oil boom has tripled linoleic acid (LA) intake since 1900, tracking the surge in cancer. This review synthesizes cutting-edge data showing how excess LA seeds oxidative lipid peroxidation, succinate-driven pseudohypoxia, mitochondrial dysfunction, hormonal-inflammatory amplification and gut dysbiosis that together create a “pro-cancer terrain”. It also challenges blanket ketogenic prescriptions, warning that carb exclusion can worsen LA-induced dysbiosis, and outlines a phased “terrain-restoration” plan: Slash dietary LA, reintroduce selective fibers, add odd-chain pentadecanoic acid and metabolic supports to revive mitophagy, microbiota and immune surveillance. The article spotlights urgent research gaps and testable clinical strategies.