Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2025; 16(7): 104727
Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.104727
Published online Jul 24, 2025. doi: 10.5306/wjco.v16.i7.104727
Impact of propofol on gastrointestinal cancer outcomes: A review of cellular behavior, growth, and metastasis
Funda Arun, Division of Anesthesiology, Department of Pedodontics, Selcuk University Faculty of Dentistry, Konya 42130, Türkiye
Oguzhan Arun, Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Konya 42130, Türkiye
Author contributions: Arun O reviewed the relevant literature, designed the concept and outline of this review, wrote, edited, and finalized the manuscript for publication; Arun F reviewed and provided critical review and edits to enhance the content.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Oguzhan Arun, MD, PhD, Professor, Department of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Alaaddin Keykubat Kampus, Konya 42130, Türkiye. oguzarun@selcuk.edu.tr
Received: January 2, 2025
Revised: March 26, 2025
Accepted: June 10, 2025
Published online: July 24, 2025
Processing time: 204 Days and 13.3 Hours
Revised: March 26, 2025
Accepted: June 10, 2025
Published online: July 24, 2025
Processing time: 204 Days and 13.3 Hours
Core Tip
Core Tip: Gastrointestinal cancers pose a significant global health concern. Surgical resection under general anesthesia serves as the primary treatment for gastrointestinal cancers. The two main anesthesia techniques utilized in cancer surgery today are propofol-based total intravenous anesthesia and volatile agent-based inhaled anesthesia. The potential impacts of the selected anesthesia technique on cancer cells, their biological behavior, and the associated clinical outcomes are subjects of extensive experimental and clinical research. Due to the conflicting findings from these studies, it remains impossible to provide personalized anesthesia recommendations based on the type of cancer and the patient’s condition.