Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. May 24, 2025; 16(5): 104154
Published online May 24, 2025. doi: 10.5306/wjco.v16.i5.104154
Role of cell cycle-related gene SAC3 domain containing 1 as a potential target of nitidine chloride in hepatocellular carcinoma progression
Qing-Ling Huang, Sheng-Sheng Zhou, Jian-Di Li, Dan-Dan Xiong, Rong-Quan He, Zhi-Guang Huang, Lei Wang, Tian-Ming Tan, Yi-Wu Dang, Wei-Jia Mo, Zhen-Bo Feng, Gang Chen, Zhen-Dong Yang
Qing-Ling Huang, Jian-Di Li, Dan-Dan Xiong, Zhi-Guang Huang, Lei Wang, Tian-Ming Tan, Yi-Wu Dang, Wei-Jia Mo, Zhen-Bo Feng, Gang Chen, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Sheng-Sheng Zhou, Rong-Quan He, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Zhen-Dong Yang, Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Co-first authors: Qing-Ling Huang and Sheng-Sheng Zhou.
Co-corresponding authors: Gang Chen and Zhen-Dong Yang.
Author contributions: Huang QL contributed to writing original draft; Huang QL, Zhou SS, Li JD, Xiong DD and He RQ contributed to methodology and data analysis; Huang ZG, Dang YW and Mo WJ contributed to writing review; Wang L, Tan TM and Feng ZB contributed to data supervision; Yang ZD and Chen G contributed to resources, supervision, writing review and editing; all authors contributed to the study conception and design, have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82160762 and No. 82460783; Guangxi Medical University “Four New” Project, No. SX202403; Innovation Project of Guangxi Graduate Education, No. JGY2023068; Guangxi Higher Education Undergraduate Teaching Reform Project, No. 2022JGA146; and China Undergraduate Innovation and Entrepreneurship Training Program, No. 202310598045.
Conflict-of-interest statement: The authors did not report a potential conflict of interest.
Data sharing statement: The raw data related to the specific experiment or analysis are available upon request from the corresponding author at chen_gang_triones@163.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Dong Yang, Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. yangzhendong@stu.gxmu.edu.cn
Received: December 13, 2024
Revised: March 26, 2025
Accepted: April 17, 2025
Published online: May 24, 2025
Processing time: 158 Days and 4.7 Hours
Core Tip

Core Tip: The role of SAC3 domain containing 1 (SAC3D1) in hepatocellular carcinoma (HCC) remains unclear. Through bioinformatic analysis, molecular docking techniques, and in vitro experiments, this study demonstrates for the first time that SAC3D1 serves as a novel target for nitidine chloride (NC), which previous studies have shown to have anti-HCC effects. Downregulation of SAC3D1 by NC may inhibit HCC progression by regulating the cell cycle, providing opportunities for novel therapeutic approaches in HCC treatment.