Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2025; 16(2): 97248
Published online Feb 24, 2025. doi: 10.5306/wjco.v16.i2.97248
Pancreatic cancer: Future challenges and new perspectives for an early diagnosis
Silvia Cocca, Giuseppina Pontillo, Marinella Lupo, Raffaele Lieto, Margherita Marocchi, Maria Marsico, Emanuela Dell'Aquila, Santi Mangiafico, Giuseppe Grande, Rita Conigliaro, Helga Bertani
Silvia Cocca, Marinella Lupo, Margherita Marocchi, Maria Marsico, Giuseppe Grande, Rita Conigliaro, Helga Bertani, Gastroenterology and Endoscopy Unit, Azienda Ospedaliero Universitaria Policlinico di Modena, Modena 41121, Italy
Giuseppina Pontillo, Gastroenterology and Endoscopy Unit, Presidio Ospedaliero San Giuseppe Moscati (Aversa, CE) – ASL Caserta, Caserta 81100, Italy
Raffaele Lieto, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples 80131, Campania, Italy
Emanuela Dell'Aquila, Department of Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome 0144, Italy
Santi Mangiafico, Gastroenterology and Endoscopy Unit, Azienda Ospedaliero Universitaria Policlinico “G Rodolico – San Marco”, Catania 95123, Sicilia, Italy
Author contributions: Cocca S, Pontillo G and Lupo M contributed to conceptualization and writing - original draft; Santi M, Lupo M, Marsico M, Marocchi M and Dell’Aquila E contributed to writing - review & editing; Conigliaro LR contributed to reviewing & editing and supervision; Lieto R and Grande G contributed to data curation and formal analysis; Marsico M, Marocchi M, Lupo M and Dell’Aquila E contributed to resources; Bertani H contributed to supervision and conceptualization.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giuseppina Pontillo, MD, Doctor, Gastroenterology and Endoscopy Unit, Presidio Ospedaliero San Giuseppe Moscati (Aversa, CE) – ASL Caserta, Via Antonio Gramsci, 1, 81031, Caserta 81100, Italy. giu.pontillo@gmail.com
Received: May 29, 2024
Revised: September 27, 2024
Accepted: October 21, 2024
Published online: February 24, 2025
Processing time: 196 Days and 5.7 Hours
Core Tip

Core Tip: Early diagnosis of pancreatic cancer or identification of its precursors can improve the prognosis of this disease, although the detection of early-stage pancreatic cancer or pre-cancerous lesions is still difficult. The current challenge is to find an effective screening system for diagnosis in “high risk” patients (elderly, hereditary syndromes, mutations, etc.). In addition to conventional imaging, endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography play a pivotal role, as well as future application of genetic and biological biomarkers in this setting.