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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 24, 2025; 16(11): 110792
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.110792
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.110792
Clinicopathological predictors of right para esophageal lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis
Mirza Muhammad Hadeed Khawar, Department of Medicine, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan
Muhammad Hanan Abid, Muhammad Bilal A Cheema, Muneeb Khawar, Muneeba Shaukat, Muhammad Huzaifa A Khan, Muneeb Saifullah, Rimsha Noureen, Ali Akram Qureshi, Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Hamza Aka Khail, Department of Medicine, Kateb University Faculty of Medicine, Kabul 1006, Afghanistan
Muhammad Abbas Khokhar, Department of Oncology and Radiotherapy, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Author contributions: Khawar MMH contributed to conceptualization; Khawar MMH, Abid MH, Shaukat M, Khan MHA, Saifullah M, Khail HA, Qureshi AA, and Khokhar MA contributed to data curation; Khawar MMH, Cheema MBA, and Khawar M contributed to writing-original draft; Khawar MMH, Khan MHA, Qureshi AA, and Khokhar MA contributed to methodology; Abid MH, Cheema MBA, Khawar M, and Noureen R contributed to formal analysis. All authors have conducted the final review and editing of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hamza Aka Khail, MD, Department of Medicine, Kateb University Faculty of Medicine, Shaheed Mazari Road, Kabul 1006, Afghanistan.
Received: June 16, 2025
Revised: June 27, 2025
Accepted: October 13, 2025
Published online: November 24, 2025
Processing time: 159 Days and 10.3 Hours
Revised: June 27, 2025
Accepted: October 13, 2025
Published online: November 24, 2025
Processing time: 159 Days and 10.3 Hours
Core Tip
Core Tip: Several factors significantly associated with right paraesophageal lymph node metastasis include age under 55 years, sex, tumor size of 1 cm, multifocality, capsular invasion, vascular invasion, extra-thyroid extension, central and lateral lymph node metastasis, Hashimoto thyroiditis, microcalcifications, and echogenicity. In contrast, tumor location and margins were not significantly associated. These findings highlight the need for thorough evaluation and proactive surgical intervention in patients with papillary thyroid carcinoma papillary thyroid carcinoma who exhibit these risk factors to manage potential right paraesophageal lymph node involvement.