Bingham G, Shetye A, Suresh R, Mirnezami R. Impact of primary tumour location on colorectal liver metastases: A systematic review. World J Clin Oncol 2020; 11(5): 294-307 [PMID: PMC7360521 DOI: 10.5306/wjco.v11.i5.294]
Corresponding Author of This Article
Reza Mirnezami, FRCS, MBBS, PhD, Consultant Colorectal Surgeon, Department of Colorectal Surgery, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, United Kingdom. reza.mirnezami@nhs.net
Research Domain of This Article
Oncology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. May 24, 2020; 11(5): 294-307 Published online May 24, 2020. doi: 10.5306/wjco.v11.i5.294
Impact of primary tumour location on colorectal liver metastases: A systematic review
George Bingham, Alysha Shetye, Reena Suresh, Reza Mirnezami
George Bingham, Reena Suresh, Department of General Surgery, St. Thomas’s Hospital, Lambeth, London SE1 7EH, United Kingdom
Alysha Shetye, Reza Mirnezami, Department of Colorectal Surgery, Royal Free Hospital, Hampstead, London NW3 2QG, United Kingdom
Author contributions: Bingham G and Shetye A have contributed equally. Bingham G, Shetye A, and Suresh R completed the initial literature review. Bingham G and Shetye A drafted the manuscript and tables. Mirnezami R developed the concept, led the editing process, and contributed to drafting the manuscript. All authors contributed to the critical revision, editing, and approval of the final version.
Conflict-of-interest statement: The authors declare no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Reza Mirnezami, FRCS, MBBS, PhD, Consultant Colorectal Surgeon, Department of Colorectal Surgery, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, United Kingdom. reza.mirnezami@nhs.net
Received: December 31, 2019 Peer-review started: December 31, 2019 First decision: March 15, 2020 Revised: May 9, 2020 Accepted: May 14, 2020 Article in press: May 14, 2020 Published online: May 24, 2020 Processing time: 144 Days and 20.1 Hours
Core Tip
Core tip: Primary tumour location is associated with differing oncological outcomes and patterns of hepatic metastatic behaviour in patients with colorectal cancer liver metastases. Specifically, this systematic review indicates that there is improved overall survival in patients undergoing treatment for colorectal cancer liver metastases with left-sided colorectal cancer (CRC), compared with right-sided CRC. These findings suggest that primary tumour location may have a role in developing more individually-tailored staging, treatment and surveillance strategies for patients with CRC in the future. Current chemotherapeutic regimens may require additional modification(s) to take into account the fundamental molecular and embryological differences that underpin primary tumour sidedness.
