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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Sep 5, 2025; 16(3): 107167
Published online Sep 5, 2025. doi: 10.4292/wjgpt.v16.i3.107167
Published online Sep 5, 2025. doi: 10.4292/wjgpt.v16.i3.107167
Comparison of endoscopic retrograde cholangiopancreatography drainage vs percutaneous transhepatic biliary drainage in severe cholangitis: A study from low-middle income country
Masood Muhammad Karim, Om Parkash, Section of Gastroenterology, Department of Medicine, Aga Khan University, Karachi 74800, Sindh, Pakistan
Sehar Moatter, Department of Gastroenterology, Aga Khan University Hospital, Karachi 74800, Sindh, Pakistan
Mashal Amin, Department of Community Medicine, Aga Khan University Hospital, Karachi 74800, Sindh, Pakistan
Co-corresponding authors: Masood Muhammad Karim and Om Parkash.
Author contributions: Karim MM and Moatter S wrote the manuscript; Amin M and Parkash O contributed to the data analysis; Karim MM and Parkash O contributed important and indispensable knowledge for the manuscript preparation as the co-corresponding authors; All authors read and approved the final manuscript.
Institutional review board statement: Institutional review board approval obtained. Number 2023-8486-24495.
Informed consent statement: Institutional review board exemption from informed consent.
Conflict-of-interest statement: No conflicts of interest.
Data sharing statement: No confidential details of the participants were shared.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Om Parkash, Associate Professor, Section of Gastroenterology, Depart
Received: March 26, 2025
Revised: May 7, 2025
Accepted: August 1, 2025
Published online: September 5, 2025
Processing time: 162 Days and 9.4 Hours
Revised: May 7, 2025
Accepted: August 1, 2025
Published online: September 5, 2025
Processing time: 162 Days and 9.4 Hours
Core Tip
Core Tip: Severe acute cholangitis is life-threatening, especially in low-middle income countries where percutaneous transhepatic biliary drainage (PTBD) is common due to limited endoscopic services. A retrospective study at Aga Khan University Hospital (2017-2023) found endoscopic retrograde cholangiopancreatography (ERCP) had higher therapeutic success (97.1%) compared with PTBD (57.1%) with PTBD having more complications (P = 0.02) and higher mortality (23.8%) compared with ERCP (0%). The study concluded that ERCP showed better outcomes, suggesting a shift towards ERCP in LMICs for severe cholangitis treatment.