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World J Radiol. Feb 28, 2026; 18(2): 115610
Published online Feb 28, 2026. doi: 10.4329/wjr.v18.i2.115610
Published online Feb 28, 2026. doi: 10.4329/wjr.v18.i2.115610
Research progress of the clinical application of dual-layer spectral computed tomography in gastrointestinal malignancies
Hong-Yu Yan, Department of Medical Imaging Center, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Bing Zhang, Department of Radiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao 266011, Shandong Province, China
Zhao-Guo Han, Department of Nuclear Medicine, NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research, Harbin 150028, Heilongjiang Province, China
Jia-Zhong Ren, Department of Medical Imaging, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan 250117, Shandong Province, China
Yan-Qing Liu, Haiyang Center for Disease Control and Prevention, Yantai 265106, Shandong Province, China
Co-first authors: Hong-Yu Yan and Bing Zhang.
Co-corresponding authors: Jia-Zhong Ren and Yan-Qing Liu.
Author contributions: Yan HY conceptualized and designed the study, drafted the original manuscript; Zhang B, Ren JZ, Han ZG, Liu YQ supervised the study; Ren JZ made critical revisions; all authors prepared the draft and approved the submitted version; Yan HY and Zhang B have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; Ren JZ and Liu YQ have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Corresponding author: Yan-Qing Liu, Haiyang Center for Disease Control and Prevention, No. 8 Haixin West Road, Longshan Street, Yantai 265106, Shandong Province, China.
Received: November 10, 2025
Revised: December 31, 2025
Accepted: January 15, 2026
Published online: February 28, 2026
Processing time: 107 Days and 3.9 Hours
Revised: December 31, 2025
Accepted: January 15, 2026
Published online: February 28, 2026
Processing time: 107 Days and 3.9 Hours
Core Tip
Core Tip: Dual-layer spectral computed tomography (DLCT) achieves true instantaneous dual-energy acquisition through innovative dual-layer detector design, accurately obtaining information for anatomical structure and spectral image. This enables DLCT distinct advantages in detecting gastrointestinal malignancies compared with traditional endoscopic examination. Abundant quantitative parameters and integration of artificial intelligence will further expand the application filed of DLCT in molecular typing, clinical stage, efficacy monitoring and precise management for gastrointestinal malignancy patients.